Vigren Lina, Tysk Curt, Ström Magnus, Kilander Anders F, Hjortswang Henrik, Bohr Johan, Benoni Cecilia, Larson Lasse, Sjöberg Klas
Department of Clinical Sciences, Division of Gastroenterology, Skåne University Hospital, Lund University, Malmö, Sweden.
Scand J Gastroenterol. 2013 Aug;48(8):944-50. doi: 10.3109/00365521.2013.805809. Epub 2013 Jun 26.
Collagenous colitis (CC) is associated with autoimmune disorders. The aim of the present study was to investigate the relationship between CC and autoimmune disorders in a Swedish multicenter study.
Patients with CC answered questionnaires about demographic data and disease activity. The patient's files were scrutinized for information about autoimmune diseases.
A total number of 116 CC patients were included; 92 women, 24 men, median age 62 years (IQR 55-73). In total, 30.2% had one or more autoimmune disorder. Most common were celiac disease (CeD; 12.9%) and autoimmune thyroid disease (ATD, 10.3%), but they also had Sjögren's syndrome (3.4%), diabetes mellitus (1.7%) and conditions in skin and joints (6.0%). Patients with associated autoimmune disease had more often nocturnal stools. The majority of the patients with associated CeD or ATD got these diagnoses before the colitis diagnosis.
Autoimmune disorders occurred in one-third of these patients, especially CeD. In classic inflammatory bowel disease (IBD), liver disease is described in contrast to CC where no cases occurred. Instead, CeD was prevalent, a condition not reported in classic IBD. Patients with an associated autoimmune disease had more symptoms. Patients with CC and CeD had an earlier onset of their colitis. The majority of the patients with both CC and CeD were smokers. Associated autoimmune disease should be contemplated in the follow-up of these patients.
胶原性结肠炎（CC）与自身免疫性疾病相关。本研究的目的是在一项瑞典多中心研究中调查CC与自身免疫性疾病之间的关系。
CC患者回答了有关人口统计学数据和疾病活动的问卷。仔细查阅患者档案以获取有关自身免疫性疾病的信息。
共纳入116例CC患者；92例女性，24例男性，中位年龄62岁（四分位间距55 - 73岁）。总共有30.2%的患者患有一种或多种自身免疫性疾病。最常见的是乳糜泻（CeD；12.9%）和自身免疫性甲状腺疾病（ATD，10.3%），但他们也患有干燥综合征（3.4%）、糖尿病（1.7%）以及皮肤和关节疾病（6.0%）。伴有自身免疫性疾病的患者夜间排便更为频繁。大多数伴有CeD或ATD的患者在结肠炎诊断之前就已得到这些诊断。
这些患者中有三分之一患有自身免疫性疾病，尤其是CeD。在经典炎症性肠病（IBD）中会描述肝脏疾病，而CC患者中未出现此类病例。相反，CeD很常见，这是经典IBD中未报告的一种情况。伴有自身免疫性疾病的患者症状更多。CC和CeD患者的结肠炎发病更早。大多数同时患有CC和CeD的患者是吸烟者。在对这些患者进行随访时应考虑到相关的自身免疫性疾病。
