早期发育中的前后模式形成：三种策略。
Anterior-posterior patterning in early development: three strategies.
作者信息
Kimelman David, Martin Benjamin L
机构信息
Department of Biochemistry, University of Washington, Seattle, WA, USA.
出版信息
Wiley Interdiscip Rev Dev Biol. 2012 Mar-Apr;1(2):253-66. doi: 10.1002/wdev.25. Epub 2011 Dec 27.
Abstract
The anterior-posterior (AP) axis is the most ancient of the embryonic axes and exists in most metazoans. Different animals use a wide variety of mechanisms to create this axis in the early embryo. In this study, we focus on three animals, including two insects (Drosophila and Tribolium) and a vertebrate (zebrafish) to examine different strategies used to form the AP axis. While Drosophila forms the entire axis within a syncytial blastoderm using transcription factors as morphogens, zebrafish uses signaling factors in a cellularized embryo, progressively forming the AP axis over the course of a day. Tribolium uses an intermediate strategy that has commonalities with both Drosophila and zebrafish. We discuss the specific molecular mechanisms used to create the AP axis and identify conserved features.
摘要
前后轴是胚胎轴中最古老的，存在于大多数后生动物中。不同的动物在早期胚胎中使用各种各样的机制来形成这个轴。在本研究中，我们聚焦于三种动物，包括两种昆虫（果蝇和赤拟谷盗）和一种脊椎动物（斑马鱼），以研究用于形成前后轴的不同策略。果蝇在合胞体胚盘中利用转录因子作为形态发生素来形成整个轴，而斑马鱼在细胞化胚胎中利用信号因子，在一天的时间里逐渐形成前后轴。赤拟谷盗采用一种与果蝇和斑马鱼都有共同之处的中间策略。我们讨论了用于创建前后轴的具体分子机制，并确定了保守特征。
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