通过四组分多米诺反应高效构建五环[苯并[b]吲哚[1,2,3-de][1,8]萘啶]衍生物。
Highly efficient construction of pentacyclic benzo[b]indeno-[1,2,3-de][1,8]naphthyridine derivatives via four-component domino reaction.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
出版信息
Chem Commun (Camb). 2013 Aug 11;49(62):6983-5. doi: 10.1039/c3cc43489c.
A series of new octahydrobenzo[b]indeno[1,2,3-de][1,8] naphthyridine and decahydropyrido[2,3,4-gh]phenanthridine derivatives were synthesized via a four-component domino reaction under microwave irradiation. This one-pot transformation, which involved multiple steps and did not require the use of a catalyst, constructed four new C-C bonds, two new C-N bonds, and three new rings, with efficient use of all reactants.
一系列新的八氢苯并[b]吲哚[1,2,3-de][1,8]萘啶和十氢化吡啶并[2,3,4-gh]菲啶衍生物通过微波辐射下的四组分多米诺反应合成。这种一锅转化涉及多个步骤，不需要使用催化剂，有效地利用了所有反应物，构建了四个新的 C-C 键、两个新的 C-N 键和三个新环。
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