Clinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.
Pan Afr Med J. 2022 Apr 28;41:344. doi: 10.11604/pamj.2022.41.344.23664. eCollection 2022.
adolescents living with HIV [ALHIV] face the dual challenges of adolescence and coping with HIV infection. This study aims to evaluate health-related quality of life [HRQoL] of children and adolescents aged 8 - 18 years living with HIV in an HIV treatment centre in Lagos, Nigeria.
we conducted a cross-sectional study among children and adolescents living with HIV and receiving antiretroviral therapy. HRQoL was assessed using the Paediatric Quality of Life Inventory [PedQoL™]. Socio-demographic data and HIV related clinical and laboratory characteristics were also obtained and tested based on HRQoL scores in order to determine if there were possible associations.
the study included 113 participants with a mean age of 14 (± 2.9) years. There was male predominance, with a male: female sex ratio of 1.1: 1. The mean duration of ART was 102.9 (±36.9) months and CD4 lymphocyte count was and 741.2 (±335.7) cell/mm. The majority of participants (62%) were also virally suppressed. Based on self-reported data, the mean physical, psychosocial and total HRQoL scores were 85.0 [± 22.4], 78.5 [±17.5] and 81.6 [±18.4] respectively. Adolescents aged 13-18 years had significantly higher scores than children aged 8-12 years. Male patients who had been on ART for ≥60 months were also significantly associated with higher HRQoL scores (OR=5.46 [CI= 2.24-13.29], p = 0.0009) and OR= 4.80, [CI= 1.58 - 14.56] p = 0.0032).
the majority of participants in the study had good HRQoL scores, attesting to the success of highly active antiretroviral therapy for HIV infection and the ease of access and availability to a comprehensive care.
感染 HIV 的青少年[ALHIV]面临着青春期和应对 HIV 感染的双重挑战。本研究旨在评估在尼日利亚拉各斯的一个艾滋病毒治疗中心接受抗逆转录病毒治疗的 8-18 岁感染 HIV 的儿童和青少年的健康相关生活质量[HRQoL]。
我们对接受抗逆转录病毒治疗的感染 HIV 的儿童和青少年进行了横断面研究。使用儿科生活质量问卷[PedQoL™]评估 HRQoL。还获得了社会人口统计学数据以及与 HIV 相关的临床和实验室特征，并根据 HRQoL 评分进行了测试，以确定是否存在可能的关联。
该研究包括 113 名参与者，平均年龄为 14（±2.9）岁。男性占优势，男女比例为 1.1:1。ART 的平均持续时间为 102.9（±36.9）个月，CD4 淋巴细胞计数为 741.2（±335.7）个细胞/mm。大多数参与者（62%）也病毒抑制。根据自我报告的数据，平均生理、心理社会和总 HRQoL 评分分别为 85.0[±22.4]、78.5[±17.5]和 81.6[±18.4]。13-18 岁的青少年得分明显高于 8-12 岁的儿童。已经接受 ART 治疗≥60 个月的男性患者的 HRQoL 评分也显著较高（OR=5.46[CI=2.24-13.29]，p=0.0009）和 OR=4.80，[CI=1.58-14.56]，p=0.0032）。
研究中的大多数参与者的 HRQoL 评分较高，这证明了高效抗逆转录病毒疗法治疗 HIV 感染的成功，以及获得全面护理的便利性和可及性。
