Short J A, Heiner D C, Hsiao R L, Andersen F L
Department of Pediatrics, Harbor-UCLA Medical Center, Torrance 90509.
J Clin Microbiol. 1990 Jul;28(7):1635-9. doi: 10.1128/jcm.28.7.1635-1639.1990.
The importance of immunoglobulin G (IgG) subclass responses in different infections has been elucidated for a number of organisms, but few parasitic organisms have been examined in this regard. In the current study, quantitative radioimmunoassays were used to examine the IgE and IgG4 subclass responses to larval Taenia solium. Patients were divided into clinically infected (CI) and probably uninfected (PU) groups. Unexposed normal subjects were used as controls. The CI group had elevated geometric mean levels of total IgE in serum (28.6 IU/ml) and specific IgG4 antibodies (438.8 arbitrary units [AU]/ml) compared with controls (8.3 IU/ml and 50.1 AU/ml, respectively). The CI group also had significantly elevated levels in cerebrospinal fluid of total IgG4 (18.6 micrograms/ml) and specific IgG4 antibodies (86.0 AU/ml) compared with the PU group (2.5 micrograms/ml and 1.6 AU/ml, respectively). There was no specific IgE antibody response detected in either the CI or PU patient group. The marked IgG4 response of CI patients to T. solium merits further investigation.
免疫球蛋白G（IgG）亚类反应在不同感染中的重要性已针对多种病原体得到阐明，但在这方面对寄生虫的研究较少。在本研究中，采用定量放射免疫分析法检测了针对猪带绦虫幼虫的IgE和IgG4亚类反应。患者被分为临床感染（CI）组和可能未感染（PU）组。未接触过病原体的正常受试者作为对照。与对照组（分别为8.3 IU/ml和50.1 AU/ml）相比，CI组血清中总IgE的几何平均水平（28.6 IU/ml）和特异性IgG4抗体（438.8任意单位[AU]/ml）升高。与PU组（分别为2.5微克/毫升和1.6 AU/ml）相比，CI组脑脊液中总IgG4（18.6微克/毫升）和特异性IgG4抗体（86.0 AU/ml）水平也显著升高。在CI组或PU组患者中均未检测到特异性IgE抗体反应。CI患者对猪带绦虫的显著IgG4反应值得进一步研究。
