Beck C S, Heiner D C
Am Rev Respir Dis. 1981 Jul;124(1):94-6. doi: 10.1164/arrd.1981.124.1.94.
Using a newly developed radioimmunoassay, 4 of 422 subjects tested were found to have an isolated absence of the immunoglobulin subclass IgG4. All had severe recurrent sinopulmonary infection. The association of these disorders with an isolated absence of IgG4 suggested that this immunoglobulin subclass may have a unique role in host respiratory tract defense mechanisms.
使用一种新开发的放射免疫分析法，在422名接受检测的受试者中，发现有4人单纯缺乏免疫球蛋白亚类IgG4。所有人都有严重的复发性鼻窦肺部感染。这些病症与单纯缺乏IgG4之间的关联表明，这种免疫球蛋白亚类可能在宿主呼吸道防御机制中具有独特作用。
