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用于评估脆弱拟杆菌肠道毒力的兔模型。

Rabbit model to evaluate enterovirulence of Bacteroides fragilis.

作者信息

Myers L L, Shoop D S, Collins J E

机构信息

Veterinary Research Laboratory, Montana State University, Bozeman 59717.

出版信息

J Clin Microbiol. 1990 Jul;28(7):1658-60. doi: 10.1128/jcm.28.7.1658-1660.1990.

DOI:10.1128/jcm.28.7.1658-1660.1990
PMID:2380388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC268010/
Abstract

Enterotoxigenic Bacteroides fragilis elicited fluid accumulation in the intestinal tract and exfoliation of epithelial cells in the proximal colon of the 2-week-old rabbit. The rabbit model was employed to screen isolates of B. fragilis for enterovirulence and to study the pathogenesis of disease caused by enterotoxigenic B. fragilis.

摘要

产肠毒素脆弱拟杆菌可引起2周龄家兔肠道积液和近端结肠上皮细胞脱落。该家兔模型用于筛选脆弱拟杆菌分离株的肠毒性，并研究产肠毒素脆弱拟杆菌所致疾病的发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0e/268010/f0435913bb45/jcm00055-0179-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0e/268010/19962e6d1335/jcm00055-0179-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0e/268010/a079962f2366/jcm00055-0179-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0e/268010/f0435913bb45/jcm00055-0179-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0e/268010/19962e6d1335/jcm00055-0179-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0e/268010/a079962f2366/jcm00055-0179-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0e/268010/f0435913bb45/jcm00055-0179-c.jpg

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Rabbit model to evaluate enterovirulence of Bacteroides fragilis.用于评估脆弱拟杆菌肠道毒力的兔模型。
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引用本文的文献

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Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes.产肠毒素脆弱拟杆菌：共生菌中的异类。
Clin Microbiol Rev. 2009 Apr;22(2):349-69, Table of Contents. doi: 10.1128/CMR.00053-08.
2
Association of enterotoxigenic Bacteroides fragilis infection with inflammatory diarrhea.产肠毒素脆弱拟杆菌感染与炎性腹泻的关联。
Clin Infect Dis. 2008 Sep 15;47(6):797-803. doi: 10.1086/591130.
3
Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway.

本文引用的文献

1
Association of enterotoxigenic Bacteroides fragilis with diarrheal disease in calves.产肠毒素脆弱拟杆菌与犊牛腹泻病的关联。
J Infect Dis. 1985 Dec;152(6):1344-7. doi: 10.1093/infdis/152.6.1344.
2
Association of enterotoxigenic Bacteroides fragilis with diarrheal disease in young pigs.产肠毒素脆弱拟杆菌与幼猪腹泻病的关联
Am J Vet Res. 1987 May;48(5):774-5.
3
Diarrhea associated with enterotoxigenic Bacteroides fragilis in foals.幼驹中与产肠毒素脆弱拟杆菌相关的腹泻
脆弱拟杆菌肠毒素通过丝裂原活化蛋白激酶和酪氨酸激酶调节的核因子-κB途径诱导肠上皮细胞分泌白细胞介素-8。
Infect Immun. 2004 Oct;72(10):5832-9. doi: 10.1128/IAI.72.10.5832-5839.2004.
4
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation.肠道上皮对肠道病原体的反应：对紧密连接屏障、离子转运和炎症的影响。
Gut. 2003 Mar;52(3):439-51. doi: 10.1136/gut.52.3.439.
5
Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro.脆弱拟杆菌毒素2在体外会损伤人结肠黏膜。
Gut. 1999 Apr;44(4):504-10. doi: 10.1136/gut.44.4.504.
6
Heterogeneity in responses by primary adult human colonic epithelial cells to purified enterotoxin of Bacteroides fragilis.原代成人结肠上皮细胞对脆弱拟杆菌纯化肠毒素反应的异质性。
Gut. 1998 Nov;43(5):651-5. doi: 10.1136/gut.43.5.651.
7
Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis.产肠毒素脆弱拟杆菌脆弱溶素致病性岛的分子特征
Infect Immun. 1998 Apr;66(4):1735-9. doi: 10.1128/IAI.66.4.1735-1739.1998.
8
The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells.脆弱拟杆菌毒素脆弱溶素破坏上皮细胞的细胞旁屏障。
Infect Immun. 1997 Apr;65(4):1431-9. doi: 10.1128/iai.65.4.1431-1439.1997.
9
Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis.人类肠道上皮细胞会肿胀，并在脆弱拟杆菌金属蛋白酶毒素的作用下表现出肌动蛋白重排。
Infect Immun. 1996 Dec;64(12):5022-8. doi: 10.1128/iai.64.12.5022-5028.1996.
10
Monoclonal antibodies to the enterotoxin of Bacteroides fragilis: production, characterization, and immunodiagnostic application.脆弱拟杆菌肠毒素单克隆抗体：制备、特性鉴定及免疫诊断应用
Clin Diagn Lab Immunol. 1996 Sep;3(5):608-10. doi: 10.1128/cdli.3.5.608-610.1996.
Am J Vet Res. 1987 Nov;48(11):1565-7.
4
Isolation of enterotoxigenic Bacteroides fragilis from humans with diarrhea.从腹泻患者中分离出产肠毒素脆弱拟杆菌。
J Clin Microbiol. 1987 Dec;25(12):2330-3. doi: 10.1128/jcm.25.12.2330-2333.1987.
5
Antigenic characteristics of enterotoxigenic and nonenterotoxigenic isolates of Bacteroides fragilis.脆弱拟杆菌产肠毒素和非产肠毒素分离株的抗原特性
Am J Vet Res. 1987 Apr;48(4):643-5.
6
Diarrheal disease caused by enterotoxigenic Bacteroides fragilis in infant rabbits.脆弱拟杆菌肠毒素引起的幼兔腹泻病
J Clin Microbiol. 1989 Sep;27(9):2025-30. doi: 10.1128/jcm.27.9.2025-2030.1989.
7
Exfoliating colitis associated with enterotoxigenic Bacteroides fragilis in a piglet.仔猪中与产肠毒素脆弱拟杆菌相关的剥脱性结肠炎。
J Vet Diagn Invest. 1989 Oct;1(4):349-51. doi: 10.1177/104063878900100413.