Division of Molecular Genetics, Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, USA; Naomi Berrie Diabetes Center, Columbia University, College of Physicians and Surgeons, New York, USA.
Obesity (Silver Spring). 2014 Mar;22(3):691-7. doi: 10.1002/oby.20528. Epub 2013 Dec 2.
To understand the regulation of adipocyte size and adipokine expression in relation to gender, anatomic location, adiposity, and metabolic risk factors in adolescents with morbid obesity.
Adipocyte size and adipokine expression in paired abdominal subcutaneous (SAT) and omental (VAT) surgical adipose tissues were related to gender, anatomic location, adiposity, and metabolic risk factors in a group of morbidly obese adolescents.
Significant depot- and/or gender-related differences in adipocyte size and adipokine expression were detected. Adjusted for body mass index, adipocyte size in both depots was larger in males than in females and was a major predictor of mRNA levels of leptin, plasminogen activator inhibitor-1, and adiponectin. Gender, but not adipocyte size, was significantly correlated with proinflammatory cytokine expression. Body mass index and waist circumference were correlated positively with VAT adipocyte size and negatively with SAT adipocyte size. VAT adiponectin and interleukin-6 expression levels were major predictors of high-density lipoprotein cholesterol concentrations, independent of gender, adiposity, and insulin sensitivity.
Adipose tissue morphology and function in obese adolescents are influenced by gender and anatomic location; the pattern of gender- and depot-related differences in adipocyte size and adipokine expression suggests that adolescent males, relative to the females, are at increased risk for obesity-related metabolic comorbidities.
了解病态肥胖青少年的脂肪细胞大小和脂肪因子表达与性别、解剖部位、肥胖程度和代谢危险因素的关系。
在一组病态肥胖青少年中，我们将腹部皮下（SAT）和网膜（VAT）手术脂肪组织中脂肪细胞大小和脂肪因子表达与性别、解剖部位、肥胖程度和代谢危险因素进行相关分析。
检测到脂肪细胞大小和脂肪因子表达存在明显的部位和/或性别差异。在调整了体重指数后，两个部位的脂肪细胞大小在男性中均大于女性，并且是瘦素、纤溶酶原激活物抑制剂-1 和脂联素 mRNA 水平的主要预测因子。性别而不是脂肪细胞大小与促炎细胞因子的表达显著相关。体重指数和腰围与 VAT 脂肪细胞大小呈正相关，与 SAT 脂肪细胞大小呈负相关。VAT 脂联素和白细胞介素-6 的表达水平是高密度脂蛋白胆固醇浓度的主要预测因子，与性别、肥胖程度和胰岛素敏感性无关。
肥胖青少年的脂肪组织形态和功能受性别和解剖部位的影响；脂肪细胞大小和脂肪因子表达的性别和部位相关差异模式表明，与女性相比，青少年男性患肥胖相关代谢合并症的风险增加。
