Chida S
Department of Obstetrics and Gynecology, Christian-Albrechts-University Hospital, Kiel, Federal Republic of Germany.
J In Vitro Fert Embryo Transf. 1990 Jun;7(3):177-9. doi: 10.1007/BF01135685.
The incidence of human identical twins after in vitro fertilization and embryo transfer (IVF-ET) is estimated to be higher than the commonly accepted incidence after conception in vivo. This paper reports that 8 mouse blastocysts which had double inner cell masses in 261 blastocysts (3.1%) were identified after fertilization in vitro and they developed into trophoblastic outgrowth formation with two inner cell masses. In contrast, only 3 monozygous double inner cell masses were observed in 526 blastocysts (0.6%) which were fertilized in vivo and cultured from the two-cell stage in vitro. It is therefore possible that fertilization in vitro predisposes to monozygous twinning.
据估计，体外受精与胚胎移植（IVF-ET）后同卵双胞胎的发生率高于体内受孕后普遍认可的发生率。本文报道，在体外受精后，261个囊胚中有8个（3.1%）具有双内细胞团，并且它们发育成带有两个内细胞团的滋养层外植体。相比之下，在526个体内受精并从二细胞期开始体外培养的囊胚中，仅观察到3个单合子双内细胞团（0.6%）。因此，体外受精可能易导致单合子孪生。
