Slotnick R N, Ortega J E
Division of Maternal-Fetal Medicine, Eastern Virginia Medical School, Norfolk 23508, USA.
J Assist Reprod Genet. 1996 May;13(5):381-5. doi: 10.1007/BF02066168.
An anonymous survey of IVF centers in the United States was employed to calculate frequencies of multiple gestation, monozygotic multiple gestation, and monoamniotic multiple gestation. Rates for zona-manipulated (ICSI, SUZI, zona drilling, mechanical assisted hatching) and non-manipulated pregnancies were compared.
From 42 IVF centers in the United States, a total of 143 pregnancies was ascertained from zona-manipulated cycles. A multiple gestation frequency of 16.1% was reported. Five monoamniotic twin gestations were identified: four from manipulated cycles and one from a nonmanipulated cycle. All monoamniotic twin gestations resulted in live births, although three showed significant intrauterine growth discordance and one newborn was diagnosed with the VATER malformation sequence.
Monoamniotic multiple gestations may be increased in zona-manipulated cycles. The potential obstetric risks and complications of zona manipulation should be discussed with patients.
对美国的体外受精（IVF）中心进行一项匿名调查，以计算多胎妊娠、单卵多胎妊娠和单羊膜囊多胎妊娠的发生率。比较了进行透明带操作（卵胞浆内单精子注射、精子输卵管内移植、透明带钻孔、机械辅助孵化）和未进行透明带操作的妊娠率。
在美国的42个IVF中心，共确定了143例来自进行透明带操作周期的妊娠。报告的多胎妊娠发生率为16.1%。鉴定出5例单羊膜囊双胎妊娠：4例来自进行操作的周期，1例来自未进行操作的周期。所有单羊膜囊双胎妊娠均分娩出活婴，尽管3例显示明显的宫内生长不一致，1例新生儿被诊断为VATER畸形序列。
进行透明带操作的周期中单羊膜囊多胎妊娠可能增加。应与患者讨论透明带操作潜在的产科风险和并发症。
