抗精神病药恶性综合征与甲状腺功能减退症
Neuroleptic malignant syndrome and hypothyroidism.
作者信息
Moore A P, Macfarlane I A, Blumhardt L D
机构信息
Department of Neurological Science, University of Liverpool, Walton Hospital, Liverpool, United Kingdom.
出版信息
J Neurol Neurosurg Psychiatry. 1990 Jun;53(6):517-8. doi: 10.1136/jnnp.53.6.517.
Abstract
Two patients with primary hypothyroidism who developed neuroleptic malignant syndrome (NMS) are described. Thyroid disease might predispose to NMS by altering brain dopamine metabolism.
摘要
本文描述了两名原发性甲状腺功能减退症患者发生了抗精神病药恶性综合征（NMS）。甲状腺疾病可能通过改变脑多巴胺代谢而使患者易患NMS。
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本文引用的文献
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The neuroleptic malignant syndrome.神经阻滞剂恶性综合征
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Current concepts. Neuroleptic malignant syndrome.当前概念。抗精神病药物恶性综合征。
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The secretory activity of the tuberoinfundibular dopaminergic neurons is modulated by the thyroid status in the adult rat: consequence on prolactin secretion.成年大鼠中，结节漏斗多巴胺能神经元的分泌活动受甲状腺状态调节：对催乳素分泌的影响。
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Modulation of dopamine receptors by thyrotropin-releasing hormone in the rat brain.促甲状腺激素释放激素对大鼠脑内多巴胺受体的调节作用
Peptides. 1987 Mar-Apr;8(2):319-25. doi: 10.1016/0196-9781(87)90107-0.
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Thyrotropin regulates thyrotroph responsiveness to dopamine in vitro.
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Idiopathic hypoparathyroidism presenting as the neuroleptic malignant syndrome.表现为抗精神病药物恶性综合征的特发性甲状旁腺功能减退症。
Br J Hosp Med. 1989 Feb;41(2):182.
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