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脱铁铁蛋白修饰的磁性颗粒作为阿霉素载体用于抗癌药物递送。

Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery.

作者信息

Blazkova Iva, Nguyen Hoai Viet, Dostalova Simona, Kopel Pavel, Stanisavljevic Maja, Vaculovicova Marketa, Stiborova Marie, Eckschlager Tomas, Kizek Rene, Adam Vojtech

机构信息

Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, Brno CZ-613 00, Czech Republic.

出版信息

Int J Mol Sci. 2013 Jun 27;14(7):13391-402. doi: 10.3390/ijms140713391.

DOI:10.3390/ijms140713391
PMID:23807501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3742193/
Abstract

Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.

摘要

磁颗粒介导的转运与基于纳米材料的药物载体相结合在靶向癌症治疗方面具有巨大潜力。在本研究中，通过激光诱导荧光检测毛细管电泳（CE-LIF）研究了阿霉素包封到脱铁铁蛋白中及其与磁性颗粒的结合。通过荧光光谱法对包封的阿霉素进行定量，并与CE-LIF进行比较。此外，通过向样品溶液中加入甲醇观察到阿霉素信号的显著增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/cc19816c591e/ijms-14-13391f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/d48523c4fa56/ijms-14-13391f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/b32f724121f7/ijms-14-13391f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/90272c6b4708/ijms-14-13391f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/e25dd1113c0e/ijms-14-13391f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/d15a87bf5976/ijms-14-13391f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/cc19816c591e/ijms-14-13391f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/d48523c4fa56/ijms-14-13391f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/b32f724121f7/ijms-14-13391f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/90272c6b4708/ijms-14-13391f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/e25dd1113c0e/ijms-14-13391f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/d15a87bf5976/ijms-14-13391f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ab/3742193/cc19816c591e/ijms-14-13391f6.jpg

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