Kudr Jiri, Haddad Yazan, Richtera Lukas, Heger Zbynek, Cernak Mirko, Adam Vojtech, Zitka Ondrej
Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-61300 Brno, Czech Republic.
Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-61600 Brno, Czech Republic.
Nanomaterials (Basel). 2017 Aug 29;7(9):243. doi: 10.3390/nano7090243.
The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired size, morphology, chemical composition, and surface chemistry. Physical and chemical stability of magnetic materials is acquired by the coating. Moreover, surface layers of polymers, silica, biomolecules, etc. can be designed to obtain affinity to target molecules. The combination of the ability to respond to the external magnetic field and the rich possibilities of coatings makes magnetic materials universal tool for magnetic separations of small molecules, biomolecules and cells. In the biomedical field, magnetic particles and magnetic composites are utilized as the drug carriers, as contrast agents for magnetic resonance imaging (MRI), and in magnetic hyperthermia. However, the multifunctional magnetic particles enabling the diagnosis and therapy at the same time are emerging. The presented review article summarizes the findings regarding the design and synthesis of magnetic materials focused on biomedical applications. We highlight the utilization of magnetic materials in separation/preconcentration of various molecules and cells, and their use in diagnosis and therapy.
越来越多关注磁性材料的科学出版物表明，更广泛的科学界对此兴趣日增。在合成具有所需尺寸、形态、化学成分和表面化学性质的磁性材料方面取得了重大进展。通过涂层可实现磁性材料的物理和化学稳定性。此外，聚合物、二氧化硅、生物分子等的表面层可经设计以获得对目标分子的亲和力。对外部磁场作出响应的能力与丰富的涂层可能性相结合，使磁性材料成为用于小分子、生物分子和细胞磁分离的通用工具。在生物医学领域，磁性颗粒和磁性复合材料被用作药物载体、磁共振成像（MRI）的造影剂以及用于磁热疗。然而，能够同时实现诊断和治疗的多功能磁性颗粒正在兴起。这篇综述文章总结了有关专注于生物医学应用的磁性材料设计和合成的研究结果。我们重点介绍了磁性材料在各种分子和细胞的分离/预浓缩中的应用，以及它们在诊断和治疗中的用途。
