Department of Research and Development, Green Molecular S.L., Parc Cientı´fic de la Universitat de Vale`ncia, Paterna, Spain.
Crit Rev Clin Lab Sci. 2013 May-Jun;50(3):65-78. doi: 10.3109/10408363.2013.805182. Epub 2013 Jul 1.
Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of this stilbene in inflammatory dermatoses and photoprotection, cancer prevention and therapy, insulin sensitivity, blood glycemia and lipid levels, cardiovascular diseases, aging, and memory and cognition are addressed. Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed. This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol. Potential benefits of using combinations of different polyphenols are considered. Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.
白藜芦醇及其天然二甲化类似物，紫檀芪，表现出相似的生物活性。然而，紫檀芪在体内更高的生物利用度是一个基本优势。本综述的主要重点是紫檀芪的生物医学应用。该查尔酮在炎症性皮肤病和光保护、癌症预防和治疗、胰岛素敏感性、血糖和血脂水平、心血管疾病、衰老以及记忆和认知方面的代谢和药代动力学。安全性和毒性，以及对未来研究和生物医学用途的建议，也进行了讨论。本综述包括紫檀芪与其他多酚之间的比较，特别强调了白藜芦醇。还考虑了使用不同多酚组合的潜在益处。基于目前的证据，我们得出结论，紫檀芪是一种活性植物营养素，也是一种具有多种生物医学应用的潜在药物。
