Department of Pathology, University of Verona, Verona, Italy; Department of Pathology, Ospedale Sacro Cuore-Don Calabria, Via don Sempreboni, 5, Negrar, 37024 Verona, Italy.
Best Pract Res Clin Gastroenterol. 2013 Apr;27(2):299-322. doi: 10.1016/j.bpg.2013.04.001.
Pancreatic cancer has a very poor prognosis, with a five year survival of only 5%. New studies have shown that it takes over 11 years for cells to develop invasive capability. This provides an opportunity to intervene if precursor lesions can be detected. This paper reviews the molecular, pathological, clinical findings and management of pancreatic intraepithelial neoplasia (PanIN), intraductal pancreatic mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN), three precursor lesions which can give rise to invasive carcinoma of the pancreas.
胰腺癌预后极差，五年生存率仅为 5%。新的研究表明，细胞具有侵袭能力需要超过 11 年的时间。如果能够检测到前驱病变，这就提供了一个干预的机会。本文综述了胰腺上皮内瘤变（PanIN）、导管内胰腺黏液性肿瘤（IPMN）和黏液性囊性肿瘤（MCN）这三种前驱病变的分子、病理学、临床发现和处理，它们都有可能发展为胰腺浸润性癌。
