Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, TU Dresden, Fetscher Street 74, 01307 Dresden, Germany.
Institute for Pathology, University Hospital Carl Gustav Carus Dresden, TU Dresden, Fetscher Street 74, 01307 Dresden, Germany.
Biomed Res Int. 2014;2014:474905. doi: 10.1155/2014/474905. Epub 2014 Mar 24.
Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic carcinoma. This paper focuses on PanIN, IPMN, and MCN lesions and reviews the current level of knowledge and clinical measures.
胰腺癌仍然是一种可怕的疾病。高死亡率主要是由于缺乏高度敏感和特异性的诊断工具，而且大多数患者在晚期和不可治愈的阶段被诊断出来。过去十年中，关于胰腺癌前体病变的知识有了显著增长，现在我们知道主要有三种病变（PanIN、IPMN 和 MCN）是导致胰腺癌发展的原因。这些病变的早期检测仍然具有挑战性，但为患者提供了在可能患上侵袭性胰腺癌之前治愈的机会。本文重点介绍 PanIN、IPMN 和 MCN 病变，并回顾当前的知识水平和临床措施。
