Liu Zhi-Qiang, Xing Shan-Shan, Zhang Wei
Jining Medical College, Shandong, People's Republic of China.
J Spinal Cord Med. 2013 Mar;36(2):147-52. doi: 10.1179/2045772312Y.0000000028.
Ischemic/reperfusion (I/R) injury of the spinal cord is a serious complication that can result from thoracoabdominal aortic surgery.
To investigate the neuroprotective effect of curcumin against I/R injury in a rabbit model.
A total of 36 rabbits were randomly divided into three groups: sham, I/R, and curcumin-treated group. Rabbits were subject to 30-min aortic occlusion to induce transient spinal cord ischemia. Neurological function was observed after reperfusion and spinal cord segment (L3-L5) was collected for histopathological evaluation. Malondialdehyde (MDA) and total superoxide dismutase (SOD) activity were also assayed.
Rabbits in I/R group were induced to paraplegia. While after 48-hour treatment, compared with I/R group, curcumin significantly improved neurological function, reduced cell apoptosis and MDA levels as well as increased SOD activity (P < 0.05).
The results suggest that curcumin, at least in an animal model, can attenuate transient spinal cord ischemic injury potentially via reducing oxidative damage, which may provide a novel approach in the treatment of spinal cord ischemic injury.
脊髓缺血/再灌注（I/R）损伤是胸腹主动脉手术可能导致的严重并发症。
研究姜黄素对兔脊髓I/R损伤的神经保护作用。
将36只兔随机分为三组：假手术组、I/R组和姜黄素治疗组。对兔进行30分钟的主动脉阻断以诱导短暂性脊髓缺血。再灌注后观察神经功能，并取脊髓节段（L3-L5）进行组织病理学评估。同时检测丙二醛（MDA）和总超氧化物歧化酶（SOD）活性。
I/R组兔出现截瘫。姜黄素治疗48小时后，与I/R组相比，神经功能明显改善，细胞凋亡和MDA水平降低，SOD活性增加（P<0.05）。
结果表明，至少在动物模型中，姜黄素可能通过减少氧化损伤来减轻短暂性脊髓缺血损伤，这可能为脊髓缺血损伤的治疗提供一种新方法。
