Instructor, School of Nursing, Chang Gung University and Doctoral Candidate, School of Nursing, National Yang-Ming University, Taipei, Taiwan, ROC.
Worldviews Evid Based Nurs. 2013 Nov;10(4):208-17. doi: 10.1111/wvn.12007. Epub 2013 Jun 27.
Fatigue is one of the most distressing and prevalent symptoms reported by pediatric oncology patients. With the increase in cancer survival rates, medical teams have focused on methods that control cancer-related fatigue in children during the disease and its treatment in order to increase the quality of life for these patients.
The objective of this systematic review was to synthesize the best available evidence concerning the effectiveness of nonpharmacological interventions for fatigue in children and adolescents with cancer.
The search strategy was designed to retrieve studies published between 1960 and 2010 in either English or Chinese. This review included randomized controlled trials and quasi-experimental studies. The studies that were selected for retrieval were assessed by two independent reviewers for methodological validity prior to inclusion in the review using standardized critical-appraisal instruments.
The review included six studies, and the meta-analysis revealed a statistically significant effect of exercise interventions in reducing general fatigue (effect size = -0.76; 95% CI [-1.35, -0.17]) in children and adolescents with cancer.
The review provides an evidence-based guide to future priorities for clinical practice. Exercise interventions could reduce the levels of general fatigue in children aged 6-18 years. In particular, exercise interventions for fatigue are feasible and safe.
疲劳是儿科肿瘤患者报告的最令人痛苦和最常见的症状之一。随着癌症存活率的提高，医疗团队专注于控制儿童癌症相关疲劳的方法，以便在疾病及其治疗过程中提高这些患者的生活质量。
本系统评价的目的是综合有关非药物干预治疗癌症儿童和青少年疲劳的最佳现有证据。
检索策略旨在检索 1960 年至 2010 年间发表的英文或中文文献。本综述包括随机对照试验和准实验研究。在纳入本综述之前，使用标准化的批判性评估工具，由两名独立的综述者对检索到的研究进行方法学有效性评估。
本综述包括 6 项研究，荟萃分析显示运动干预可显著降低癌症儿童和青少年的一般疲劳（效应量=-0.76；95%CI[-1.35，-0.17]）。
本综述为未来的临床实践提供了循证指导。运动干预可以降低 6-18 岁儿童的一般疲劳水平。特别是，针对疲劳的运动干预是可行且安全的。
