Department of Paediatric Neurology, Catholic University, Rome, Italy.
Neuromuscul Disord. 2013 Aug;23(8):624-8. doi: 10.1016/j.nmd.2013.06.001. Epub 2013 Jul 1.
The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients.
我们的纵向多中心研究的目的是确定在 12 个月的时间内，III 型 SMA 型可走动患儿和成人的 6 分钟步行测试（6MWT）的变化。38 名可走动的 III 型患者在基线和基线后 12 个月进行了 6MWT。在基线时，6 分钟内覆盖的距离在 75 到 510m 之间（平均值为 294.91，SD 为 127），而在 12 个月时，距离在 50 到 611m 之间（平均值为 293.41m，SD 为 141）。基线和 12 个月之间的平均距离变化为-1.46（SD 为 50.1；范围：-183 至 131.8m）。即使是进入青春期的年轻患者，与老年患者相比，他们的恶化程度超过 30m 的风险相对较高，但变化与年龄或基线值无关（p>.05）。我们的发现提供了使用 6MWT 在可走动的 SMA 患者中进行的首次纵向数据。
