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6 个月内，与无治疗相比，Icon 树脂渗透治疗多托槽引起的白垩斑对美观改善的耐久性：一项单中心、劈裂口腔、随机临床试验。

Durability of esthetic improvement following Icon resin infiltration of multibracket-induced white spot lesions compared with no therapy over 6 months: a single-center, split-mouth, randomized clinical trial.

机构信息

Department of Orthodontics, University of Göttingen, Göttingen, Germany.

出版信息

Am J Orthod Dentofacial Orthop. 2013 Jul;144(1):86-96. doi: 10.1016/j.ajodo.2013.02.029.

DOI:10.1016/j.ajodo.2013.02.029

PMID:23810050

Abstract

INTRODUCTION

White spot lesions that form during orthodontic treatment are a problem for patients and clinicians. Lesion infiltration with low-viscosity light-cured resin has been proposed as a treatment to inhibit further demineralization. The purpose of this study was to assess the durability of assimilation of white spot lesions and sound adjacent enamel achieved over 6 months with resin infiltration.

METHODS

Twenty-one consecutive subjects with 231 noncavitated, unrestored white spot lesions after multibracket treatment were recruited at the Department of Orthodontics, University of Göttingen (Germany), for lesion infiltration. A simple randomized, split-mouth, controlled design was used to allocate subjects to the treatment and control groups. In the treatment group, white spot lesion infiltration of the anterior teeth was performed with low-viscosity light-cured resin after enamel conditioning with a 15% HCl gel. Color and lightness of the white spot lesions and the sound adjacent enamel were assessed with a spectrophotometer before infiltration and after 1 day, 1 week, 4 weeks, 3 months, and 6 months, using the system of the Commission Internationale de l'Eclairage. Multifactorial analysis of variance with repeated measures and pair-wise comparisons were used to analyze the effects of infiltration and time elapsed on the color differences at an α level of 5% and a power of 80%.

RESULTS

Analysis of 20 subjects and 39 quadrants in each group (108 teeth in the control group; 111 teeth in the treatment group) showed that both parameters of treatment and time duration had globally a highly significant influence on the color difference values. Assimilation of white spot lesion color to the surrounding enamel after infiltration was stable with no significant changes over 6 months; the mean color difference of white spot lesions vs sound adjacent enamel (ΔE baseline vs 6 months) was 2.55 (95% confidence interval [CI], 1.431-3.678). The untreated control teeth showed no significant changes over 6 months compared with the baseline: mean (ΔE), 0.29 (95% CI, -0.335-0.928). No important adverse events or side effects were observed.

CONCLUSIONS

Resin infiltration improves the esthetic appearance of demineralized teeth. The results showed sufficient durability over 6 months.

摘要

介绍

正畸治疗过程中形成的白斑是患者和临床医生的一个问题。已经提出用低粘度光固化树脂对病变进行渗透，以抑制进一步脱矿。本研究的目的是评估在 6 个月内用树脂渗透治疗对白斑和相邻正常釉质的同化的耐久性。

方法

在德国哥廷根大学正畸系，连续招募了 21 名接受多托槽治疗后有 231 个非龋、未修复的白斑的连续患者，进行病变渗透。采用简单随机、分侧、对照设计，将患者分配到治疗组和对照组。在治疗组中，在前牙用低粘度光固化树脂进行白斑渗透，用 15%盐酸凝胶进行牙釉质预处理。用分光光度计在渗透前和渗透后 1 天、1 周、4 周、3 个月和 6 个月，用国际照明委员会的系统评估白斑和相邻正常釉质的颜色和亮度。采用重复测量的多因素方差分析和两两比较，分析渗透和时间对色差的影响，α水平为 5%，功率为 80%。

结果

对 20 名患者和每组 39 个象限（对照组 108 颗牙；治疗组 111 颗牙）进行分析，结果显示，治疗和时间两个参数都对色差值有显著的影响。渗透后白斑颜色与周围釉质的同化是稳定的，6 个月内没有明显的变化；白斑与正常相邻釉质的平均色差（基线与 6 个月）为 2.55（95%置信区间[CI]，1.431-3.678）。未经治疗的对照组牙齿与基线相比在 6 个月内没有明显变化：平均（ΔE），0.29（95%CI，-0.335-0.928）。未观察到重要的不良事件或副作用。