Deyhimi Parviz, Keshani Forouz, Azmoudeh Faezeh, Hashemzadeh Zahra
Torabinejad Dental Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Iran.
Dent Res J (Isfahan). 2012 Dec;9(Suppl 1):S127-31.
Lymphoma is a malignant neoplasm of lymphoid tissue which is divided into 2 groups: Hodgkin and non-Hodgkin. About 85% of non-Hodgkin lymphomas are B-cell lymphomas, and T-cell lymphomas are unusual. Anaplastic large cell lymphoma (ALCL) is a kind of non-Hodgkin lymphoma with T or NK cell origin that is rarely seen in the oral cavity and only 10 cases have been reported up to now. Here we present a case of ALCL metastasized to the oral cavity in a 32- year- old man with pervious history of ALCL which caused an ulceration in the posterior area of the hard palate. Radiography showed irregular resorption of alveolar bone. Histopathologic examination of the incisional biopsy revealed neoplastic proliferation of large and bizarre cells with hyperchromatic nuclei and numerous giant cells and atypical mitoses. Immunohistochemistry markers (CK, LCA, CD3, CD30, CD20) confirmed the diagnosis of ALCL.
淋巴瘤是淋巴组织的恶性肿瘤，分为两组：霍奇金淋巴瘤和非霍奇金淋巴瘤。约85%的非霍奇金淋巴瘤是B细胞淋巴瘤，T细胞淋巴瘤较为少见。间变性大细胞淋巴瘤（ALCL）是一种起源于T或NK细胞的非霍奇金淋巴瘤，在口腔中罕见，迄今为止仅报道过10例。在此，我们报告一例32岁男性，既往有ALCL病史，现发生ALCL转移至口腔，导致硬腭后部溃疡。影像学检查显示牙槽骨不规则吸收。切开活检的组织病理学检查显示，大的奇异细胞呈肿瘤性增殖，核染色质增多，可见大量巨细胞和非典型有丝分裂。免疫组织化学标记物（CK、LCA、CD3、CD30、CD20）证实为ALCL。
