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口腔癌早期诊断中的分子预测指标

Molecular predictors in the early diagnosis of oral cancer.

作者信息

Rajkumari S, Sathiyajeeva J, Kumar C Santhosh, Sunil P M, Thayumanavan B

机构信息

Senior Lecturer, Department of Oral Pathology, Sathyabama University Dental College and Hospital , Chennai, India .

出版信息

J Clin Diagn Res. 2013 May;7(5):942-4. doi: 10.7860/JCDR/2013/5058.2983. Epub 2013 Mar 21.

DOI:10.7860/JCDR/2013/5058.2983
PMID:23814751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3681078/
Abstract

Human beings are being subjected to a variety of disease processes, a majority of which can be cured. However, cancer remains an endangering disease that affects various body parts. Though cancers can be prevented by various therapeutic modalities, the patient survival and the prognosis are questionable, as they are detected at very late stages. The aim of improving the prognosis lies in an early detection of the cancer, which can be brought about by an analysis of the changes in the cellular biomolecules.

摘要

人类正遭受各种疾病的折磨，其中大多数疾病是可以治愈的。然而，癌症仍然是一种危及生命的疾病，会影响身体的各个部位。尽管可以通过各种治疗方式预防癌症，但由于癌症往往在非常晚期才被发现，患者的生存率和预后仍存在疑问。改善预后的关键在于早期发现癌症，而这可以通过分析细胞生物分子的变化来实现。

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本文引用的文献

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Polymorphism of angiotensin I-converting enzyme gene is related to oral cancer and lymph node metastasis in male betel quid chewers.血管紧张素转化酶基因多态性与男性嚼槟榔者口腔癌及淋巴结转移有关。
Oral Oncol. 2012 Dec;48(12):1257-62. doi: 10.1016/j.oraloncology.2012.06.003. Epub 2012 Jul 7.
2
Biomarkers of oral premalignant epithelial lesions for clinical application.口腔癌前上皮病变的生物标志物用于临床应用。
Oral Oncol. 2012 Jul;48(7):578-84. doi: 10.1016/j.oraloncology.2012.01.017. Epub 2012 Feb 18.
3
Expression of inducible nitric oxide synthase (iNOS) in oral precancer and oral squamous cell carcinoma: an immunohistochemical study.诱导型一氧化氮合酶 (iNOS) 在口腔癌前病变和口腔鳞状细胞癌中的表达：免疫组织化学研究。
Cancer Biomark. 2010;8(3):155-60. doi: 10.3233/CBM-2011-0207.
4
Diagnostic clinical aids in oral cancer.口腔癌的诊断临床辅助工具。
Oral Oncol. 2010 Jun;46(6):418-22. doi: 10.1016/j.oraloncology.2010.03.006. Epub 2010 Apr 3.
5
Molecular biology: an early detector of oral cancers.分子生物学：口腔癌的早期检测手段
Ann Diagn Pathol. 2009 Apr;13(2):140-5. doi: 10.1016/j.anndiagpath.2008.12.003.
6
Molecular techniques and genetic alterations in head and neck cancer.头颈部癌症中的分子技术和基因改变。
Oral Oncol. 2009 Apr-May;45(4-5):335-9. doi: 10.1016/j.oraloncology.2008.05.015. Epub 2008 Jul 31.
7
Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice.将头颈部癌症的分子生物学和表观遗传学应用于日常临床实践。
Oral Oncol. 2009 Apr-May;45(4-5):440-6. doi: 10.1016/j.oraloncology.2008.05.013. Epub 2008 Jul 31.
8
Cytokeratin fragments in the serum: their utility for the management of oral cancer.血清中的细胞角蛋白片段：其在口腔癌管理中的应用
Oral Oncol. 2008 Aug;44(8):722-32. doi: 10.1016/j.oraloncology.2007.10.008. Epub 2008 Jan 18.
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