载脂蛋白基因 SNP+45 和 SNP+276 与动脉粥样硬化外周动脉疾病的相关性：病例对照研究。
Association of atherosclerotic peripheral arterial disease with adiponectin genes SNP+45 and SNP+276: a case-control study.
机构信息
Department of Surgery, 2nd Surgical Clinic, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, 4-6 Clinicilor, 400006 Cluj-Napoca, Romania.
出版信息
Biomed Res Int. 2013;2013:501203. doi: 10.1155/2013/501203. Epub 2013 Jun 3.
OBJECTIVES
We hypothesized that adiponectin gene SNP+45 (rs2241766) and SNP+276 (rs1501299) would be associated with atherosclerotic peripheral arterial disease (PAD). Furthermore, the association between circulating adiponectin levels, fetuin-A, and tumoral necrosis factor-alpha (TNF-α) in patients with atherosclerotic peripheral arterial disease was investigated.
METHOD
Several blood parameters (such as adiponectin, fetuin-A, and TNF-α) were measured in 346 patients, 226 with atherosclerotic peripheral arterial disease (PAD) and 120 without symptomatic PAD (non-PAD). Two common SNPs of the ADIPOQ gene represented by +45T/G 2 and +276G/T were also investigated.
RESULTS
Adiponectin concentrations showed lower circulating levels in the PAD patients compared to non-PAD patients (P < 0.001). Decreasing adiponectin concentration was associated with increasing serum levels of fetuin-A in the PAD patients. None of the investigated adiponectin SNPs proved to be associated with the subjects' susceptibility to PAD (P > 0.05).
CONCLUSION
The results of our study demonstrated that neither adiponectin SNP+45 nor SNP+276 is associated with the risk of PAD.
目的
我们假设脂联素基因 SNP+45（rs2241766）和 SNP+276（rs1501299）与动脉粥样硬化性外周动脉疾病（PAD）相关。此外，还研究了动脉粥样硬化性外周动脉疾病患者循环脂联素水平、胎球蛋白-A 和肿瘤坏死因子-α（TNF-α）之间的关系。
方法
在 346 名患者中测量了几种血液参数（如脂联素、胎球蛋白-A 和 TNF-α），其中 226 名患者患有动脉粥样硬化性 PAD，120 名患者无症状 PAD（非-PAD）。还研究了 ADIPOQ 基因的两个常见 SNP，分别由+45T/G2 和+276G/T 代表。
结果
与非-PAD 患者相比，PAD 患者的脂联素浓度显示出较低的循环水平（P<0.001）。在 PAD 患者中，脂联素浓度的降低与胎球蛋白-A 血清水平的升高相关。在所研究的脂联素 SNP 中，没有一个与 PAD 患者的易感性相关（P>0.05）。
结论
我们的研究结果表明，脂联素 SNP+45 或 SNP+276 均与 PAD 的风险无关。
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