具有早期高级别转化阶段的涎腺腺样囊性癌：病例报告并免疫组织化学分析。

Salivary adenoid cystic carcinoma with an early phase of high-grade transformation: case report with an immunohistochemical analysis.

机构信息

Pathology Division, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

出版信息

Diagn Pathol. 2013 Jul 2;8:113. doi: 10.1186/1746-1596-8-113.

BACKGROUND

The early phase of salivary gland carcinomas with high-grade transformation (HGT) is extremely rare. We reported one case of adenoid cystic carcinoma (AdCC) with early HGT, herein.

CASE PRESENTATION

The patient was a 27-year-old Japanese woman who suffered from swelling of the left parotid region. Most of this tumor consisted of typical AdCC histology, whereas the central area of this tumor was composed of solid growth component by atypical cells with clear cytoplasm and marked nuclear atypia. Immunohistochemically, this area was strongly and diffusely positive for epithelial membrane antigen, p53, p16, Her-2, cyclin A and cyclin B1. The Ki-67 labeling index of this area was high, entirely different from that of AdCC area.

CONCLUSION

Overall, this area was an early phase of AdCC-HGT. This case is the second case of early AdCC-HGT. We discuss the development of salivary gland carcinoma with HGT.

VIRTUAL SLIDES

http://www.diagnosticpatology.diagnomx.eu/vx/1598278104895730.

背景

伴有高级别转化（HGT）的唾液腺癌早期阶段极为罕见。我们在此报告一例伴有早期 HGT 的腺样囊性癌（AdCC）。

病例介绍

患者为 27 岁日本女性，因左侧腮腺区肿胀就诊。该肿瘤大部分由典型的 AdCC 组织学构成，而肿瘤中央区域则由具有透明细胞质和显著核异型性的不典型细胞的实性生长成分构成。免疫组织化学染色显示，该区域上皮膜抗原、p53、p16、Her-2、细胞周期蛋白 A 和细胞周期蛋白 B1 均强阳性且弥漫阳性。该区域的 Ki-67 标记指数很高，与 AdCC 区域完全不同。