Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China.
Diagn Pathol. 2012 Sep 3;7:118. doi: 10.1186/1746-1596-7-118.
Epithelioid angiosarcoma of the parotid gland is rare, and may pose a great diagnostic challenge. We report a case of primary epithelioid angiosarcoma in a 64-year-old male without history of radiation. The histopathological findings demonstrated a high grade epithelioid neoplasm. Immunostaining showed that the tumor was positive for the pan-cytokeratin, p63, cytokeratin18, Vimentin and vascular markers CD31, and was negative for CD34, cytokeratin5/6, cytokeratin7, cytokeratin20, CD68, CD30, S-100, HMB45, desmin, α-SMA and CD45. The tumor was diagnosed as an epithelioid angiosarcoma. To our knowledge, this is the first reported case of angiosarcoma which showed common positivity for cytokeratin and p63. In addition to cytokeratin, p63 is considered a useful marker for carcinoma. The co-expression of cytokeratin and p63 in epithelioid angiosarcoma represents a diagnostic pitfall. Thus, using a panel of antibodies is essential for distinguishing this tumor from poorly differentiated carcinoma. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6548916707504750.
腮腺上皮样血管肉瘤罕见，诊断极具挑战性。我们报告一例 64 岁男性原发性上皮样血管肉瘤，无放疗史。组织病理学检查显示高级别上皮样肿瘤。免疫组化显示肿瘤细胞广谱细胞角蛋白、p63、细胞角蛋白 18、波形蛋白阳性，CD34、细胞角蛋白 5/6、细胞角蛋白 7、细胞角蛋白 20、CD68、CD30、S-100、HMB45、结蛋白、α-SMA 和 CD45 阴性。诊断为上皮样血管肉瘤。据我们所知，这是首例报道的上皮样血管肉瘤 CK 和 p63 共同阳性的病例。除 CK 外，p63 被认为是癌的有用标志物。上皮样血管肉瘤中 CK 和 p63 的共表达是一个诊断陷阱。因此，使用一组抗体对于鉴别该肿瘤与低分化癌至关重要。虚拟切片：本文的虚拟切片可以在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/6548916707504750。
