Bigham-Sadegh Amin, Karimi Iraj, Alebouye Mahsa, Shafie-Sarvestani Zahra, Oryan Ahmad
Departments of Veterinary Surgery and Radiology, School of Veterinary Medicine, Shahrekord University, Shahrekord,
J Vet Sci. 2013;14(3):337-43. doi: 10.4142/jvs.2013.14.3.337. Epub 2013 Jun 28.
The present study was conducted to compare the effects of xenogenic bovine fetal demineralized bone matrix (DBM), commercial DBM, omentum, omentum-calf fetal DBM, cortical autograft and xenogenic cartilage powder on the healing of tibial defects in a dog model to determine the best material for bone healing. Seven male adult mongrel dogs, weighing 26.2 ± 2.5 kg, were used in this study. Seven holes with a diameter of 4-mm were created and then filled with several biomaterials. Radiographs were taken postoperatively on day 1 and weeks 2, 4, 6, 8. The operated tibias were removed on the 56th postoperative day and histopathologically evaluated. On postoperative days 14, 42 and 56, the lesions of the control group were significantly inferior to those in the other group (p < 0.05). On the 28th postoperative day, the autograft group was significantly superior to the control and omentum groups (p < 0.05). Moreover, calf fetal DBM was significantly superior to the control group. There was no significant difference between the histopathological sections of all groups. Overall, the omentum and omentum-DBM groups were superior to the control group, but inferior to the autograft, commercial-DBM, calf fetal DBM and calf fetal cartilage groups.
本研究旨在比较异种牛胎儿脱矿骨基质（DBM）、市售DBM、大网膜、大网膜-小牛胎儿DBM、皮质自体骨移植和异种软骨粉对犬模型胫骨缺损愈合的影响，以确定促进骨愈合的最佳材料。本研究使用了7只体重为26.2±2.5kg的成年雄性杂种犬。制作7个直径为4mm的骨洞，然后用几种生物材料填充。术后第1天以及术后第2、4、6、8周拍摄X光片。术后第56天取出手术的胫骨并进行组织病理学评估。术后第14、42和56天，对照组的损伤明显低于其他组（p<0.05）。术后第28天，自体骨移植组明显优于对照组和大网膜组（p<0.05）。此外，小牛胎儿DBM组明显优于对照组。所有组的组织病理学切片之间无显著差异。总体而言，大网膜组和大网膜-DBM组优于对照组，但低于自体骨移植组、市售DBM组、小牛胎儿DBM组和小牛胎儿软骨组。
