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近乎闭塞患者的颈动脉支架置入术:单中心经验及与近期研究的比较

Carotid artery stenting in patients with near occlusion: a single-center experience and comparison with recent studies.

作者信息

Son Seungnam, Choi Dae Seob, Kim Soo-Kyoung, Kang Heeyoung, Park Ki-Jong, Choi Nack-Cheon, Kwon Oh-Young, Lim Byeong Hoon

机构信息

Department of Neurology, Gyeongsang National University School of Medicine, Jinju, South Korea; Gyeongnam Regional Cardiocerebrovascular Disease Center, Jinju, South Korea.

出版信息

Clin Neurol Neurosurg. 2013 Oct;115(10):1976-81. doi: 10.1016/j.clineuro.2013.06.001. Epub 2013 Jun 29.

Abstract

OBJECTIVE

The optimal management strategy for carotid artery near occlusion is still controversial. Nevertheless, prior studies about carotid artery stenting in patients with near occlusion reported both technically and clinically inspiring results. To define the effectiveness, safety, and clinical outcomes of carotid artery stenting in patients with near occlusion, we analyzed our experiences and compared with recent studies.

METHODS

We performed 24 carotid artery stenting procedures in 24 patients with near occlusion between January 2010 and July 2012. The patient group comprised 20 men (83.3%) and four women (16.7%) with a mean age of 69.5 years (range, 53-85 years). Eighteen patients had prior stroke or transient ischemic attack (75%), and six patients were asymptomatic (25%).

RESULTS

Successful stent insertion was achieved in 23 of 24 patients (95.8%). Cerebral hyperperfusion syndrome and post-procedural vascular events occurred in four patients, and all of these developed within 24h after the procedure (17.4%; two: hyperperfusion syndrome, two: acute myocardial infarction). The mean follow-up period after carotid artery stenting was 16.7±9.2 months (range, 6-32 months). No stroke related to carotid artery stenting or significant restenosis of the inserted stent developed during the follow-up period.

CONCLUSIONS

Carotid artery stenting in patients with near occlusion seems to be a technically feasible and effective method to prevent stroke recurrence. But hyperperfusion syndrome and post-procedural vascular event rates may be high, as shown in this study.

摘要

目的

颈动脉近闭塞的最佳治疗策略仍存在争议。然而,先前关于颈动脉近闭塞患者行颈动脉支架置入术的研究在技术和临床方面均取得了鼓舞人心的结果。为明确颈动脉近闭塞患者行颈动脉支架置入术的有效性、安全性及临床结局,我们分析了自身经验并与近期研究进行比较。

方法

2010年1月至2012年7月期间,我们对24例颈动脉近闭塞患者进行了24例颈动脉支架置入手术。患者组包括20名男性(83.3%)和4名女性(16.7%),平均年龄69.5岁(范围53 - 85岁)。18例患者既往有中风或短暂性脑缺血发作(75%),6例患者无症状(25%)。

结果

24例患者中有23例成功置入支架(95.8%)。4例患者发生了脑过度灌注综合征和术后血管事件,且均在术后24小时内出现(17.4%;2例:过度灌注综合征,2例:急性心肌梗死)。颈动脉支架置入术后的平均随访期为16.7±9.2个月(范围6 - 32个月)。随访期间未发生与颈动脉支架置入相关的中风或置入支架的明显再狭窄。

结论

颈动脉近闭塞患者行颈动脉支架置入术似乎是预防中风复发的一种技术上可行且有效的方法。但如本研究所示,过度灌注综合征和术后血管事件发生率可能较高。

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