Brennan F T, Arbakov D, Stefankiewicz J S, Groves W G, Wiebelhaus V D
Proc Soc Exp Biol Med. 1975 Jul;149(3):725-30. doi: 10.3181/00379727-149-38887.
Pentagastrin, histamine, urecholine, DBcAMP, and cGMP were all potent stimulants of acid secretion in the isolated stomach of the fed rat. With the exception of histamine and cGMP, all of these compounds were inactive when the stomach of the fasted rat was used. Pentagastrin was most effective when given on the serosal surface while histamine was equally potent whether it was added to the mucosal or serosal surface of the isolated stomach. The test would appear to be a relatively simply, but effective system for studying the basic mechanisms of action of several important secretagogues in the rat.
在喂食大鼠的离体胃中，五肽胃泌素、组胺、乌拉胆碱、二丁酰环磷腺苷（DBcAMP）和环鸟苷酸（cGMP）都是胃酸分泌的强效刺激物。除组胺和cGMP外，当使用禁食大鼠的胃时，所有这些化合物均无活性。五肽胃泌素经浆膜表面给药时效果最佳，而组胺无论添加到离体胃的粘膜表面还是浆膜表面，其效力均相同。该试验似乎是一个相对简单但有效的系统，用于研究大鼠体内几种重要促分泌素的基本作用机制。
