Chang Su-Hsin, Pollack Lisa M, Colditz Graham A
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America.
PLoS One. 2013 Jun 18;8(6):e66550. doi: 10.1371/journal.pone.0066550. Print 2013.
The objectives of this paper are to predict life years lost associated with obesity-related diseases (ORDs) for U.S. non-smoking adults, and to examine the relationship between those ORDs and mortality. Data from the National Health Interview Survey, 1997-2000, were used. We employed mixed proportional hazard models to estimate the association between those ORDs and mortality and used simulations to project life years lost associated with the ORDs. We found that obesity-attributable comorbidities are associated with large decreases in life years and increases in mortality rates. The life years lost associated with ORDs is more marked for younger adults than older adults, for blacks than whites, for males than females, and for the more obese than the less obese. Using U.S. non-smoking adults aged 40 to 49 years as an example to illustrate percentage of the life years lost associated with ORDs, we found that the mean life years lost associated with ORDs for U.S. non-smoking black males aged 40 to 49 years with a body mass index above 40 kg/m(2) was 5.43 years, which translates to a 7.5% reduction in total life years. White males of the same age range and same degree of obesity lost 5.23 life years on average - a 6.8% reduction in total life years, followed by black females (5.04 years, a 6.5% reduction in life years), and white females (4.7 years, a 5.8% reduction in life years). Overall, ORDs increased chances of dying and lessened life years by 0.2 to 11.7 years depending on gender, race, BMI classification, and age.
本文的目的是预测美国非吸烟成年人因肥胖相关疾病（ORDs）而损失的生命年数，并研究这些ORDs与死亡率之间的关系。使用了1997 - 2000年国家健康访谈调查的数据。我们采用混合比例风险模型来估计这些ORDs与死亡率之间的关联，并使用模拟方法来预测与ORDs相关的生命年数损失。我们发现，肥胖所致的合并症与生命年数大幅减少和死亡率增加相关。与ORDs相关的生命年数损失在年轻成年人中比在年长成年人中更显著，在黑人中比在白人中更显著，在男性中比在女性中更显著，在肥胖程度较高者中比在肥胖程度较低者中更显著。以40至49岁的美国非吸烟成年人为例来说明与ORDs相关的生命年数损失百分比，我们发现，体重指数高于40 kg/m²的40至49岁美国非吸烟黑人男性因ORDs平均损失的生命年数为5.43年，这相当于总生命年数减少了7.5%。同一年龄范围且肥胖程度相同的白人男性平均损失5.23个生命年——总生命年数减少6.8%，其次是黑人女性（5.04年，生命年数减少6.5%）和白人女性（4.7年，生命年数减少5.8%）。总体而言，ORDs增加了死亡几率，并使生命年数减少了0.2至11.7年，具体取决于性别、种族、体重指数分类和年龄。
