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尿失禁患者尿液挥发物中释放的主要气味物质。

Major odorants released as urinary volatiles by urinary incontinent patients.

机构信息

Atmospheric Environment Laboratory, Department of Environment & Energy, Sejong University, Seoul 143-747, Korea.

出版信息

Sensors (Basel). 2013 Jul 3;13(7):8523-33. doi: 10.3390/s130708523.

DOI:10.3390/s130708523
PMID:23823973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3758608/
Abstract

In this study, volatile urinary components were collected using three different types of samples from patients suffering from urinary incontinence (UI): (1) urine (A); (2) urine + non-used pad (B); and (3) urine + used pad (C). In addition, urine + non-used pad (D) samples from non-patients were also collected as a reference. The collection of urinary volatiles was conducted with the aid of a glass impinger-based mini-chamber method. Each of the four sample types (A through D) was placed in a glass impinger and incubated for 4 hours at 37 °C. Ultra pure air was then passed through the chamber, and volatile urine gas components were collected into Tedlar bags at the other end. These bag samples were then analyzed for a wide range of VOCs and major offensive odorants (e.g., reduced sulfur compounds (RSCs), carbonyls, trimethylamine (TMA), ammonia, etc.). Among the various odorants, sulfur compounds (methanethiol and hydrogen sulfide) and aldehydes (acetaldehyde, butylaldehyde, and isovaleraldehyde) were detected above odor threshold and predicted to contribute most effectively to odor intensity of urine incontinence.

摘要

在这项研究中,使用三种不同类型的样本从患有尿失禁(UI)的患者中收集挥发性尿液成分:(1)尿液(A);(2)尿液+未使用的垫子(B);和(3)尿液+使用过的垫子(C)。此外,还收集了非患者的尿液+未使用的垫子(D)样本作为参考。挥发性尿液的收集是借助基于玻璃冲击器的微型室方法进行的。将四种样本类型(A 到 D)中的每一种都放在玻璃冲击器中,并在 37°C 下孵育 4 小时。然后将超纯空气通过腔室,挥发性尿液气体成分被收集到特氟隆袋的另一端。然后对这些袋样本进行了广泛的 VOC 和主要恶臭物质(例如,还原硫化合物(RSCs)、羰基、三甲胺(TMA)、氨等)的分析。在各种气味物质中,检测到硫化合物(甲硫醇和硫化氢)和醛(乙醛、丁醛和异戊醛)超过气味阈值,并预测它们对尿失禁尿液气味强度的贡献最大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab60/3758608/b0bd88447b19/sensors-13-08523f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab60/3758608/e54eb3ff2dc3/sensors-13-08523f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab60/3758608/b0bd88447b19/sensors-13-08523f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab60/3758608/e54eb3ff2dc3/sensors-13-08523f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab60/3758608/b0bd88447b19/sensors-13-08523f2a.jpg

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