Nutritional Epidemiology Research Department, Sorbonne Paris Cité Research Center, Inserm U557, Inra UMR1125, Cnam, Paris 13 University, F-93017, Bobigny Cedex, France.
Int J Cancer. 2014 Jan 15;134(2):445-59. doi: 10.1002/ijc.28365. Epub 2013 Aug 5.
Data are lacking regarding the association of alcohol consumption with a broad range of other cancer risk factors.
(i) to assess which sociodemographic, lifestyle and dietary factors were associated with alcohol consumption; (ii) to identify profiles of alcohol consumers by beverage type; (iii) to estimate the number of cancer risk factors accumulated on the individual level according to alcohol consumption. Alcohol and dietary intakes were assessed by six 24 hr records among 29,566 adults of the NutriNet-Santé cohort. Factors associated with alcohol consumption (nondrinkers (reference)/< 10 g/day/≥ 10 g/day) were assessed by polytomic multivariate logistic regression stratified by gender. Among alcohol consumers, percentages of alcohol brought by each beverage type were compared across sociodemographic and lifestyle characteristics using Kruskal-Wallis rank tests. Several factors were associated with alcohol consumption ≥ 10 g/day in both genders: older age (p(men)=0.02, p(women)<0.0001), smoking (p(men&women) < 0.0001), higher socioprofessional category (p(men&women)<0.0001), higher income (p(men)=0.003, p(women)<0.0001) and less healthy dietary intakes. Profiles of subjects varied across alcoholic beverage types. Men with history of cardiovascular disease (p=0.0002) or depression (p=0.03) and women with history of cirrhosis (p<0.0001) consumed less alcohol. In women, personal history of cancer was associated with a lower proportion of moderate alcohol users only (< 10 g/day, p=0.04). In both genders, higher alcohol drinkers clustered more cancer risk factors (median=5, apart from alcohol) than nondrinkers (median=4), p< .0001. The multiplicity of deleterious lifestyle behaviors combined with alcohol drinking must be taken into account in cancer prevention efforts. Gender-specific medical advice for people with personal or family history of alcohol-related diseases, including cancer, should be strengthened.
关于饮酒与广泛的其他癌症风险因素之间的关联，数据仍存在空白。
(i)评估哪些社会人口统计学、生活方式和饮食因素与饮酒有关；(ii)按饮料类型确定饮酒者的特征；(iii)根据饮酒量估计个体层面上积累的癌症风险因素的数量。在 NutriNet-Santé 队列中，对 29566 名成年人进行了六次 24 小时记录，以评估酒精和饮食摄入量。采用多变量逻辑回归对非饮酒者（参考）/<10 g/天/>10 g/天）与性别分层。在饮酒者中，使用 Kruskal-Wallis 秩检验比较不同社会人口统计学和生活方式特征下各饮料类型的酒精摄入量百分比。在两性中，与饮酒量≥10 g/天相关的因素包括：年龄较大（男性 p=0.02，女性 p<0.0001）、吸烟（男性和女性 p<0.0001）、社会经济地位较高（男性和女性 p<0.0001）、收入较高（男性 p=0.003，女性 p<0.0001）和更不健康的饮食摄入。不同类型的酒精饮料与不同的饮酒者特征相关。患有心血管疾病（p=0.0002）或抑郁症（p=0.03）的男性和患有肝硬化的女性饮酒量较少（p<0.0001）。在女性中，只有个人癌症史与较少的中度饮酒者相关（<10 g/天，p=0.04）。在两性中，高饮酒者比非饮酒者（中位数=4，除酒精外）聚集了更多的癌症风险因素（中位数=5），p<0.0001。在癌症预防工作中，必须考虑到多种有害的生活方式行为与饮酒相结合。对于有个人或家族酒精相关疾病（包括癌症）史的人，应该加强性别特异性的医学建议。
