Am J Epidemiol. 2013 Sep 15;178(6):921-7. doi: 10.1093/aje/kwt057. Epub 2013 Jul 3.
Fetal exposure to the perfluoroalkyl acids, perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), has been associated with lower birth weight and lower weight and body mass index (weight (kg)/height (m)(2)) in early infancy. It is, however, unclear if exposure to prenatal PFOS and PFOA has a lasting influence on growth. We estimated the associations between the maternal plasma level of PFOS or PFOA and the children's body mass index, waist circumference, and risk of overweight at 7 years of age. A total of 1,400 women were randomly selected from the Danish National Birth Cohort among those who provided blood samples early in pregnancy and gave birth to liveborn singletons in 1996-2002. Weight and height information at 7 years was available for 811 children. Multiple linear and logistic regression models were used for analyses. Maternal PFOS and PFOA concentrations were overall inversely but nonsignificantly associated with the children's body mass index, waist circumference, and risk of overweight at 7 years of age. In conclusion, plasma levels of PFOS and PFOA in pregnant women did not seem to have any appreciable influence on their children's anthropometry at this point in childhood.
胎儿暴露于全氟烷基酸（PFOS 和 PFOA）与出生体重降低以及婴幼儿早期的体重和体重指数（体重（kg）/身高（m）（2））降低有关。然而，接触产前 PFOS 和 PFOA 是否会对生长产生持久影响尚不清楚。我们评估了母体血浆中 PFOS 或 PFOA 水平与儿童 7 岁时的体重指数、腰围和超重风险之间的相关性。在 1996-2002 年期间，从丹麦全国出生队列中随机选择了 1400 名在妊娠早期提供血样且生育单胎活产儿的女性。811 名儿童可提供 7 岁时的体重和身高信息。采用多元线性和逻辑回归模型进行分析。总的来说，母亲 PFOS 和 PFOA 浓度与儿童 7 岁时的体重指数、腰围和超重风险呈负相关，但无统计学意义。总之，孕妇血浆中 PFOS 和 PFOA 的水平似乎在此儿童时期并未对其子女的人体测量学产生任何明显影响。
