Høyer Birgit Bjerre, Ramlau-Hansen Cecilia Høst, Vrijheid Martine, Valvi Damaskini, Pedersen Henning Sloth, Zviezdai Valentyna, Jönsson Bo A G, Lindh Christian H, Bonde Jens Peter, Toft Gunnar
Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark.
Environ Health Perspect. 2015 Aug;123(8):841-6. doi: 10.1289/ehp.1408881. Epub 2015 Mar 26.
In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse.
We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 SD) and waist-to-height ratio (WHtR) > 0.5 at 5-9 years of age.
Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analyzed for PFOA and PFOS using liquid chromatography-tandem mass spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorized (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalized linear models.
Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 [95% confidence interval (CI): 0.82, 1.53] in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For 1-ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis.
The results indicate that prenatal PFOA and PFOS exposures may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposures were not associated with overweight.
在一些动物研究中，全氟烷基物质被认为会导致体重增加。针对这些关联的人类流行病学研究较少。
我们检测了孕妇血清中全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）的浓度，以及5至9岁后代超重（>1个标准差）和腰高比（WHtR）>0.5的患病率。
使用液相色谱 - 串联质谱法分析了1022名来自格陵兰岛和哈尔科夫（乌克兰）的INUENDO队列（2002 - 2004年）孕妇血清中的PFOA和PFOS。在随访（2010 - 2012年）时，使用广义线性模型计算了与连续和分类（三分位数）PFOA和PFOS相关的超重和腰高比>0.5的相对风险（RR）。
合并后的PFOA中位数（范围）为1.3（0.2 - 5.1），PFOS中位数（范围）为10.8（0.8 - 73.0）ng/mL。在格陵兰儿童中，孕期PFOA每增加一个自然对数单位（ln单位），后代超重的校正RR为1.11 [95%置信区间（CI）：0.82，1.53]。在乌克兰儿童中，孕期PFOA每增加一个ln单位，后代超重调整RR为1.02（95%CI：0.72，1.44）。在特定国家或合并分析中，产前暴露于PFOS与超重无关。在合并分析中，产前暴露于PFOA每增加一个ln单位，腰高比 > 0.5的校正RR为1.30（95%CI：0.97，1.74）。对于产前暴露于PFOS增加1个ln单位，合并分析中腰高比>0.5的校正RR为1.38（95%CI：1.05，1.82）。
结果表明，产前暴露于PFOA和PFOS可能与儿童腰高比>0.5有关。产前暴露于PFOA和PFOS与超重无关。
