Division of Cancer Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Cancer Sci. 2013 Oct;104(10):1271-7. doi: 10.1111/cas.12227. Epub 2013 Aug 7.
The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer.
Hippo 通路是一条进化上保守的激酶级联反应，参与细胞生长、凋亡、发育和迁移。它对干细胞自我更新和基因组稳定性的维持也至关重要。此外，该通路具有感知组织架构方面的独特能力，如细胞极性和周围微环境施加的机械张力，并能控制器官的大小和形状。所有这些特性在肿瘤细胞中经常发生改变。在这篇综述中，我们总结了哺乳动物 Hippo 信号转导失调如何与癌症有关。
