Duncan I J, Hurst N P, Sebben R, Milazzo S C, Disney A
Rheumatology Unit, Queen Elizabeth Hospital, Woodville, South Australia.
Ann Rheum Dis. 1990 Jun;49(6):378-82. doi: 10.1136/ard.49.6.378.
The prevalence of grade III or IV osteoarthritis was determined in 210 patients with chronic renal failure, of whom 94 were receiving chronic haemodialysis and 116 had functioning renal transplants. The prevalence of grade III or IV osteoarthritis was three times greater in patients under 65 than in a control population, and all but two affected patients also had erosion of subchondral bone in at least one affected joint. The excess of osteoarthritis was apparent in both the transplant recipients and those receiving haemodialysis. Over the age of 65 there was no significant difference in prevalence. Metabolic bone disease, including osteopenia, might contribute to the development of erosive osteoarthritis in chronic renal failure.
在210例慢性肾衰竭患者中确定了III级或IV级骨关节炎的患病率，其中94例接受慢性血液透析，116例有功能正常的肾移植。65岁以下患者中III级或IV级骨关节炎的患病率是对照人群的三倍，除两名受影响患者外，所有受影响患者至少一个受影响关节的软骨下骨也有侵蚀。骨关节炎的超额患病率在移植受者和接受血液透析的患者中均很明显。65岁以上患病率无显著差异。包括骨质减少在内的代谢性骨病可能促成慢性肾衰竭中侵蚀性骨关节炎的发生。
