组胺诱导克隆的类风湿性滑膜细胞产生前列腺素E2 。
Production of prostaglandin E2 induced by histamine by cloned rheumatoid synovial cells.
作者信息
Sasano M, Goto M, Nishioka K
机构信息
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
出版信息
Ann Rheum Dis. 1990 Jul;49(7):504-6. doi: 10.1136/ard.49.7.504.
Abstract
Production of prostaglandin E2, with or without histamine stimulation, by three different types of cloned rheumatoid synovial cells (macrophage like, dendritic, and fibroblast like) was evaluated. The ability of these cloned cells to respond to histamine on a cell to cell basis was as follows: macrophage like cells responded most strongly, followed by dendritic cells, followed by fibroblast like cells. Production of prostaglandin E2, stimulated by histamine, may have a role in bony destruction in rheumatoid joints.
摘要
评估了三种不同类型的克隆类风湿性滑膜细胞（巨噬细胞样、树突状和成纤维细胞样）在有或没有组胺刺激的情况下前列腺素E2的产生情况。这些克隆细胞在细胞间对组胺作出反应的能力如下：巨噬细胞样细胞反应最强烈，其次是树突状细胞，然后是成纤维细胞样细胞。组胺刺激产生的前列腺素E2可能在类风湿性关节的骨质破坏中起作用。
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