Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, UK; Veterinary Pathology, School of Veterinary Science, University of Liverpool, UK; MRC Centre for Drug Safety Science, University of Liverpool, UK.
Toxicology. 2013 Dec 15;314(2-3):262-6. doi: 10.1016/j.tox.2013.06.003. Epub 2013 Jul 3.
Polyethylene glycols (PEGs) are commonly employed as excipients in preclinical studies and in vitro experiments to dissolve poorly hydrosoluble drugs. Their use is generally considered safe in both animals and humans; however, limited data is available concerning the safety of PEGs when administered parenterally. The results of our investigation demonstrate that PEG-400 can have an irritant effect on serosal surfaces and causes subcapsular hepatocellular necrosis in mice when administered intraperitoneally at a high dose (4 mL/kg). Accordingly, levels of serum biomarkers of liver injury need to be carefully interpreted in studies where PEG is administered intraperitoneally and always in association with the results of the histological assessment.
聚乙二醇（PEGs）常用于临床前研究和体外实验中，作为溶解水溶性差的药物的赋形剂。在动物和人体中，通常认为它们的使用是安全的；然而，关于 PEG 经肠胃外给药时的安全性，可用的数据有限。我们的研究结果表明，PEG-400 腹腔内给药（4 毫升/千克）时对浆膜表面有刺激性作用，并导致小鼠肝包膜下肝细胞坏死。因此，在给予 PEG 腹腔内给药的研究中，需要仔细解释血清肝损伤生物标志物的水平，并始终结合组织学评估的结果。
