Health risk from As contaminated fish consumption by population living around River Chenab, Pakistan.

We analyzed six edible fish species (Securicola gora; Cirrhinus reba; Rita rita; Sperata sarvari; Culpisoma naziri and Labeo kalbasu) to evaluation As contamination. These species were caught from the River Chenab of Pakistan. The aim of this study was to determine the concentration of arsenic (As) and the antioxidant response in the muscle, liver and gills. The sampling sites were divided into agricultural, industrial and urban land uses. Although, the highest concentration of As, and the antioxidant activity was found in the liver, but the muscles also had a high concentration of As than that of gills. The range of As detected in these tissues was in the following order: Liver (0.009-3.95μgg(-1))>muscles (0.006-3.5μgg(-1))>gills (0.002-2.96μgg(-1)). Furthermore, the R. rita showed the highest concentration of As (2.18μgg(-1)) followed by S. sarvari (1.98μgg(-1)). The median concentrations of As, in the liver and muscles were also above the FAO/WHO, EPA permissible limits. The LPO activity was significantly related to As, which showed a possibility of cell membrane damage in these species. The human health risk assessment revealed that higher than normal concentration of As in muscle was particularly hazardous for the younger population.