Environmental Biology and Ecotoxicology Laboratory, Department of Environmental Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad PO 45320, Pakistan.
Environmental Biology and Ecotoxicology Laboratory, Department of Environmental Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad PO 45320, Pakistan.
Environ Toxicol Pharmacol. 2013 Sep;36(2):579-587. doi: 10.1016/j.etap.2013.05.015. Epub 2013 Jun 10.
We analyzed six edible fish species (Securicola gora; Cirrhinus reba; Rita rita; Sperata sarvari; Culpisoma naziri and Labeo kalbasu) to evaluation As contamination. These species were caught from the River Chenab of Pakistan. The aim of this study was to determine the concentration of arsenic (As) and the antioxidant response in the muscle, liver and gills. The sampling sites were divided into agricultural, industrial and urban land uses. Although, the highest concentration of As, and the antioxidant activity was found in the liver, but the muscles also had a high concentration of As than that of gills. The range of As detected in these tissues was in the following order: Liver (0.009-3.95μgg(-1))>muscles (0.006-3.5μgg(-1))>gills (0.002-2.96μgg(-1)). Furthermore, the R. rita showed the highest concentration of As (2.18μgg(-1)) followed by S. sarvari (1.98μgg(-1)). The median concentrations of As, in the liver and muscles were also above the FAO/WHO, EPA permissible limits. The LPO activity was significantly related to As, which showed a possibility of cell membrane damage in these species. The human health risk assessment revealed that higher than normal concentration of As in muscle was particularly hazardous for the younger population.
我们分析了六种食用鱼类（Securicola gora；Cirrhinus reba；Rita rita；Sperata sarvari；Culpisoma naziri 和 Labeo kalbasu）以评估砷的污染情况。这些鱼类均来自巴基斯坦的 Chenab 河。本研究的目的是确定肌肉、肝脏和鳃中砷的浓度和抗氧化反应。采样点分为农业、工业和城市用地。尽管砷和抗氧化活性的最高浓度出现在肝脏中，但肌肉中的砷浓度也高于鳃。这些组织中检测到的砷浓度范围如下：肝脏（0.009-3.95μg/g）>肌肉（0.006-3.5μg/g）>鳃（0.002-2.96μg/g）。此外，R. rita 表现出最高的砷浓度（2.18μg/g），其次是 S. sarvari（1.98μg/g）。肝脏和肌肉中砷的中位数浓度也高于粮农组织/世卫组织、美国环保署的允许限度。LPO 活性与砷显著相关，这表明这些物种的细胞膜可能受到了损伤。人类健康风险评估显示，肌肉中砷的浓度高于正常水平对年轻人群尤其危险。
