Lee Seulki, Han Kyu-Ho, Nakamura Yumi, Kawakami Sakura, Shimada Ken-ichiro, Hayakawa Touru, Onoue Hirotake, Fukushima Michihiro
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
Biosci Biotechnol Biochem. 2013;77(7):1430-4. doi: 10.1271/bbb.130083. Epub 2013 Jul 7.
L-cysteine works as a precursor of the antioxidant, glutathione. We investigated the effects of L-cysteine (1% and 2%) on lipid metabolism and the antioxidative system in rats fed a normal diet. Administering L-cysteine dependently decreased the food intake, fat mass weight and body weight dose. Dietary L-cysteine also decreased the triglyceride levels in the serum and liver. However, there were no significant differences in the hepatic TBARS and glutathione (GSH) levels among the groups. The activities of catalase and glutathione reductase in the rats receiving 2% L-cysteine were significantly higher (p<0.05) than in the control rats. These results suggest that dietary L-cysteine dose-dependently affected the antioxidative enzyme activities, and the lipid levels in the serum and liver which might be related to the reduced food intake.
L-半胱氨酸作为抗氧化剂谷胱甘肽的前体发挥作用。我们研究了L-半胱氨酸（1%和2%）对正常饮食喂养大鼠脂质代谢和抗氧化系统的影响。给予L-半胱氨酸会依赖性地降低食物摄入量、脂肪质量和体重剂量。饮食中的L-半胱氨酸还降低了血清和肝脏中的甘油三酯水平。然而，各组之间肝脏丙二醛（TBARS）和谷胱甘肽（GSH）水平没有显著差异。接受2%L-半胱氨酸的大鼠中过氧化氢酶和谷胱甘肽还原酶的活性显著高于对照大鼠（p<0.05）。这些结果表明，饮食中的L-半胱氨酸剂量依赖性地影响抗氧化酶活性以及血清和肝脏中的脂质水平，这可能与食物摄入量减少有关。
