大鼠发育过程中脑和肝脏中蛋白质二硫键异构酶基因表达的调控

Regulation of protein disulfide isomerase gene expression in brain and liver during rat development.

作者信息

Mira E, Castaño J G

机构信息

Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.

出版信息

Biochem Biophys Res Commun. 1990 Jul 31;170(2):421-5. doi: 10.1016/0006-291x(90)92108-c.

DOI:10.1016/0006-291x(90)92108-c

PMID:2383249

Abstract

A 4-fold increase in protein disulfide isomerase (PDI) mRNA is observed in brain of 10 days-old rats and in liver of 20 days-old foetuses when compared with 20 days-old (brain) and 18 days-old (liver) foetuses respectively. During further postnatal development, the mRNA for PDI decreases in both organs to the initial values present in foetuses and remains practically unchanged in brain till the adult. By contrast in liver by 35-40 days after birth, and coincident with sexual maturation, there is a 2.5-fold increase in PDI mRNA that is maintained by 55 days (adult). These results clearly show that protein disulfide isomerase gene expression is differentially regulated in liver and brain during rat development.

摘要

与20日龄（脑）和18日龄（肝）胎儿相比，在10日龄大鼠的脑中以及20日龄胎儿的肝中观察到蛋白质二硫键异构酶（PDI）mRNA增加了4倍。在出生后的进一步发育过程中，两个器官中PDI的mRNA均降至胎儿期的初始值，并且在脑中直到成年期几乎保持不变。相比之下，在出生后35 - 40天的肝脏中，与性成熟同时发生的是，PDI mRNA增加了2.5倍，并在55天（成年）时保持这一水平。这些结果清楚地表明，在大鼠发育过程中，蛋白质二硫键异构酶基因表达在肝脏和脑中受到不同的调节。