Shah Rakesh, Mahajan Amit, Shah Navin, Dadhania Ashish P
Department of Oral and Maxillofacial Surgery, K. M. Shah Dental College and Hospital, Piparia, Vadodara, Gujarat, India.
Natl J Maxillofac Surg. 2012 Jul;3(2):144-7. doi: 10.4103/0975-5950.111368.
We have evaluated efficacy of diclofenac sodium as pre-emptive analgesia agent in a prospective triple blind placebo controlled randomized clinical trial in a patients undergoing third molar impaction surgery.
Randomization of groups was done by randomization software and two groups were constituted one group receiving placebo pre operatively and then the drug for next five days while the other group was given diclofenac sodium pre operatively and then for five days.
Results were achieved with help of measurement of outcome variables like postoperative tenderness, swelling and trismus on a visual analogous scale (VAS) and other personalized scale. Collected data shows that there is a significant reduction in the score of postop tenderness in experimental group (P = 0.00), while there is a minimal difference between score of postoperative swelling and tenderness (P > 0.04).
So, we can conclude that use of diclofenac sodium as a preemptive analgesic agent is beneficial for better pain control in third molar impaction surgery.
我们在一项前瞻性三盲安慰剂对照随机临床试验中，评估了双氯芬酸钠作为预防性镇痛药物在接受第三磨牙阻生拔除术患者中的疗效。
通过随机软件进行分组随机化，组成两组，一组术前接受安慰剂，随后五天接受药物治疗，另一组术前给予双氯芬酸钠，随后五天也给予该药物。
借助视觉模拟量表（VAS）和其他个性化量表对术后压痛、肿胀和牙关紧闭等结局变量进行测量得出结果。收集的数据显示，实验组术后压痛评分显著降低（P = 0.00），而术后肿胀和压痛评分之间差异极小（P > 0.04）。
因此，我们可以得出结论，在第三磨牙阻生拔除术中，使用双氯芬酸钠作为预防性镇痛药物有利于更好地控制疼痛。
