Histomorphometry and Stereology Research Centre, Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran. ; Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71348-45794, Iran.
Exp Neurobiol. 2013 Jun;22(2):96-106. doi: 10.5607/en.2013.22.2.96. Epub 2013 Jun 27.
Behavioral characteristics of the animal models and humans are impaired in chronic stress. The present study aimed to evaluate and compare the protective effects of sertraline and curcumin on stress-induced learning and memory impairment, anxiety and anhedonia in rats. Male rats were divided into seven groups: stress+water, stress+olive oil, stress+curcumin (100 mg/kg/day), stress+sertraline (10 mg/kg/day), curcumin, sertraline, and control groups. The rats were exposed to chronic variable stress for 56 days. At the end of 40 days and while the previous treatments were continued, the rats were tested in the eight radial maze, elevated plus maze, and sucrose consumption for learning and memory, anxiety, and anhedonia, respectively. In comparison to the non-stressed group, stress+water and stress+olive oil groups revealed a significantly lower percent of correct choices and higher reference and working memory errors during learning and retention phases (p<0.001). In addition these stress groups showed a significant lower percent of the open arms time and open arms entries in the elevated plus maze and consuming less sucrose solution. In addition, the stress+curcumin and stress+sertraline groups showed a better performance in the evaluated parameters of the radial arm maze, elevated plus maze, and sucrose consumption tests. It appears that curcumin and sertraline have the similar effectiveness on behavioral changes in chronic variable stress-induced rats.
慢性应激会损害动物模型和人类的行为特征。本研究旨在评估和比较舍曲林和姜黄素对大鼠应激诱导的学习和记忆障碍、焦虑和快感缺失的保护作用。雄性大鼠被分为七组：应激+水、应激+橄榄油、应激+姜黄素（100mg/kg/天）、应激+舍曲林（10mg/kg/天）、姜黄素、舍曲林和对照组。大鼠接受慢性可变应激 56 天。在第 40 天结束时，在继续进行之前的治疗的同时，大鼠分别在八臂迷宫、高架十字迷宫和蔗糖消耗测试中进行学习和记忆、焦虑和快感缺失的测试。与非应激组相比，应激+水和应激+橄榄油组在学习和保留阶段的正确选择百分比明显降低，参考和工作记忆错误明显增加（p<0.001）。此外，这些应激组在高架十字迷宫中的开放臂时间和进入开放臂的百分比以及蔗糖溶液的消耗量明显减少。此外，应激+姜黄素和应激+舍曲林组在评估的放射臂迷宫、高架十字迷宫和蔗糖消耗测试的参数中表现出更好的性能。姜黄素和舍曲林似乎对慢性可变应激诱导的大鼠的行为变化具有相似的效果。
