Khoigani Masoomeh Goodarzi, Goli Shadi, Hasanzadeh Akbar
School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran J Nurs Midwifery Res. 2012 Feb;17(2 Suppl 1):S165-70.
Considering the relationship of low and high levels of hemoglobin and hematocrit with some pregnancy complications, we decided to study their relationship with pregnancy outcome. This study also aimed to investigate the changes in hemoglobin and hematocrit values during the second and first half of pregnancy and its relationship with pregnancy outcome.
In a prospective cohort study, 520 Iranian pregnant women, aged 15 to 45 years that were supported by health centers in Isfahan, Iran, were recruited using quota sampling method. Exclusion criteria comprised of 36 conditions that were related to the maternal and infant outcomes. Hemoglobin and hematocrit were measured in eligible mothers during the 6(th)-11(th) weeks and 26(th)-30(th) weeks of pregnancy. They were monitored until delivery and the data regarding their pregnancy outcome were collected.
Low levels of hemoglobin during the first half of pregnancy was associated with preeclampsia (p = 0.024). Moreover, low levels of hemoglobin during the second half of pregnancy was associated with the risk of preterm premature rupture of membranes (p = 0.01). In addition, mothers with lower blood dilution, as a physiological process during pregnancy, were more prone to preeclampsia (p = 0.04).
Hemoglobin levels in the first and second half of pregnancy can predict preeclampsia and premature preterm rupture of membranes. Increased hematocrit levels in the second half of pregnancy or lack of reduction of hematocrit levels in the second half compared to the first half can estimate preeclampsia.
考虑到血红蛋白和血细胞比容水平的高低与某些妊娠并发症的关系，我们决定研究它们与妊娠结局的关系。本研究还旨在调查妊娠前半期和后半期血红蛋白和血细胞比容值的变化及其与妊娠结局的关系。
在一项前瞻性队列研究中，采用配额抽样方法招募了520名年龄在15至45岁之间、由伊朗伊斯法罕的健康中心提供支持的伊朗孕妇。排除标准包括36种与母婴结局相关的情况。在妊娠第6至11周和第26至30周对符合条件的母亲进行血红蛋白和血细胞比容测量。对她们进行监测直至分娩，并收集有关其妊娠结局的数据。
妊娠前半期血红蛋白水平低与子痫前期相关（p = 0.024）。此外，妊娠后半期血红蛋白水平低与胎膜早破风险相关（p = 0.01）。另外，作为妊娠期间的一种生理过程，血液稀释程度较低的母亲更容易患子痫前期（p = 0.04）。
妊娠前半期和后半期的血红蛋白水平可预测子痫前期和胎膜早破。妊娠后半期血细胞比容水平升高或与前半期相比后半期血细胞比容水平未降低可用于子痫前期的评估。
