Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan.
Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Nutrients. 2021 Mar 1;13(3):810. doi: 10.3390/nu13030810.
Few epidemiologic studies have examined the role of maternal iron status in allergic diseases in offspring and findings have been inconsistent. We used a large birth cohort in Japan to explore the association of the markers for maternal iron status (maternal hemoglobin, hematocrit and dietary iron intake during pregnancy) with allergy development in offspring during early childhood. We analyzed information on children age 0-3 years from the Japan Environment and Children's Study (JECS). We used logistic models and generalized estimating equation models to evaluate the effect of maternal hemoglobin and hematocrit levels and dietary iron intake on allergies in children. Models were also fitted with propensity score-matched datasets. Data were collected for a total of 91,247 mother-child pairs. The prevalence (95% confidence interval) of low hemoglobin and hematocrit was 14.0% (13.7-14.2%) and 12.5% (12.3-12.8%), respectively. After adjusting confounders, low hemoglobin and hematocrit during pregnancy were not associated with childhood allergic outcomes. Findings from models with propensity score-matched datasets also indicated that children born to mothers with low hemoglobin or hematocrit levels during pregnancy did not have a higher risk of developing allergic conditions at 3 years old. We found no meaningful associations between low energy adjusted maternal dietary iron intake and allergies in children. In conclusion, using birth cohort data, we found no evidence supporting an association of low maternal hemoglobin, hematocrit and low dietary iron intake with allergy symptoms during early childhood. Further studies with more suitable proxy markers for blood iron status are needed.
很少有流行病学研究探讨母体铁状态在后代过敏疾病中的作用，而且研究结果也不一致。我们使用日本的一个大型出生队列来探讨母体铁状态标志物（母体血红蛋白、血细胞比容和孕期铁摄入量）与儿童早期过敏发展之间的关联。我们分析了来自日本环境与儿童研究（JECS）的 0-3 岁儿童信息。我们使用逻辑模型和广义估计方程模型来评估母体血红蛋白和血细胞比容水平以及孕期铁摄入量对儿童过敏的影响。模型还拟合了倾向评分匹配数据集。共收集了 91247 对母子数据。低血红蛋白和低血细胞比容的患病率（95%置信区间）分别为 14.0%（13.7-14.2%）和 12.5%（12.3-12.8%）。调整混杂因素后，孕期低血红蛋白和低血细胞比容与儿童期过敏结局无关。倾向评分匹配数据集模型的结果也表明，孕期母体血红蛋白或血细胞比容水平低的儿童在 3 岁时患过敏症的风险没有增加。我们没有发现低能量调整后的母体膳食铁摄入量与儿童过敏之间存在有意义的关联。总之，使用出生队列数据，我们没有发现证据支持低母体血红蛋白、低血细胞比容和低膳食铁摄入量与儿童早期过敏症状之间存在关联。需要进一步研究更适合血液铁状态的替代标志物。
