巴氯芬治疗持续性呃逆：病例系列。
Baclofen in the treatment of persistent hiccup: a case series.
机构信息
Department of Internal Medicine, Catholic University of Rome, Italy.
出版信息
Int J Clin Pract. 2013 Sep;67(9):918-21. doi: 10.1111/ijcp.12184. Epub 2013 Jul 8.
Abstract
BACKGROUND
Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.
AIM
To test baclofen administration for the treatment of persistent hiccup.
METHOD
We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.
RESULTS
Hiccup stopped in all patients after a single administration of the drug.
CONCLUSIONS
Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.
摘要
背景
持续性呃逆对患者来说是一个令人担忧的症状，因为这会降低生活质量，对医生来说也是如此，因为他们对治疗失败感到沮丧。
目的
测试巴氯芬治疗持续性呃逆。
方法
我们报告了一系列 7 例持续性呃逆患者成功接受巴氯芬治疗的病例。
结果
所有患者在单次用药后呃逆均停止。
结论
巴氯芬是 GABA（B）受体激动剂。可以想象，GABA（B）受体刺激减少多巴胺释放能够中断呃逆的反射弧。
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