Department of Pharmaceutical Biosciences, Pharmacometrics research Group, Uppsala University, Uppsala, Sweden.
CPT Pharmacometrics Syst Pharmacol. 2013 Jun 26;2(6):e50. doi: 10.1038/psp.2013.24.
Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integrated workbench for modeling and simulation with NONMEM. During the tutorial, we provide some guidance on what diagnostics we consider most useful in pharmacokinetic model development and how to construct them using these tools.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e50; doi:10.1038/psp.2013.24; advance online publication 26 June 2013.
有几个软件工具可用于方便 NONMEM 软件的使用并扩展其功能。本教程展示了三个常用且免费的工具(Pirana、PsN 和 Xpose)如何形成一个用于 NONMEM 建模和模拟的紧密集成工作台。在本教程中,我们提供了一些关于我们认为在药代动力学模型开发中最有用的诊断方法的指导,以及如何使用这些工具构建它们。CPT:《药物代谢动力学与系统药理学》(2013 年)2,e50;doi:10.1038/psp.2013.24;2013 年 6 月 26 日在线提前发布。