Jonsson E N, Karlsson M O
Department of Pharmacy, Uppsala University, Sweden.
Comput Methods Programs Biomed. 1999 Jan;58(1):51-64. doi: 10.1016/s0169-2607(98)00067-4.
The building of population pharmacokinetic/pharmacodynamic (PK/PD) models is a time consuming and complicated task. This is partly due the lack of specialized tools for the visualization and exploration requirements of this type of analysis. In this paper we present Xpose, a model building aid for population PK/PD analysis using NONMEM, which simplifies the task of producing documentation, data set checkout plots, goodness of fit plots and graphical model comparison. It also facilitates covariate model building by the use of stepwise generalized additive modeling (GAM), bootstrap of the GAM analyses and tree based modeling. The plots and analyses are presented in the form of a text based menu system and the only thing the user has to do is to make NONMEM produce one or more table files named in a specific way.
构建群体药代动力学/药效学（PK/PD）模型是一项耗时且复杂的任务。部分原因在于缺乏针对此类分析的可视化和探索需求的专业工具。在本文中，我们介绍了Xpose，一种用于使用NONMEM进行群体PK/PD分析的模型构建辅助工具，它简化了生成文档、数据集检查图、拟合优度图和图形模型比较的任务。它还通过使用逐步广义相加模型（GAM）、GAM分析的自助法和基于树的建模来促进协变量模型构建。这些图和分析以基于文本的菜单系统形式呈现，用户唯一要做的就是让NONMEM生成一个或多个以特定方式命名的表格文件。
