Santos Francisco, Correia Magda, Nóbrega-Pereira Sandrina, Bernardes de Jesus Bruno
Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Faculdade de Medicina, Instituto de Medicina Molecular João Lobo Antunes, Universidade de Lisboa, Lisboa, Portugal.
Front Physiol. 2021 Jan 20;11:583191. doi: 10.3389/fphys.2020.583191. eCollection 2020.
Aging imposes a barrier for tissue regeneration. In the heart, aging leads to a severe rearrangement of the cardiac structure and function and to a subsequent increased risk of heart failure. An intricate network of distinct pathways contributes to age-related alterations during healthy heart aging and account for a higher susceptibility of heart disease. Our understanding of the systemic aging process has already led to the design of anti-aging strategies or to the adoption of protective interventions. Nevertheless, our understanding of the molecular determinants operating during cardiac aging or repair remains limited. Here, we will summarize the molecular and physiological alterations that occur during aging of the heart, highlighting the potential role for long non-coding RNAs (lncRNAs) as novel and valuable targets in cardiac regeneration/repair.
衰老对组织再生构成障碍。在心脏中，衰老会导致心脏结构和功能的严重重塑，并随后增加心力衰竭的风险。一个由不同途径组成的复杂网络促成了健康心脏衰老过程中与年龄相关的变化，并导致心脏病易感性增加。我们对全身衰老过程的理解已经促成了抗衰老策略的设计或保护性干预措施的采用。然而，我们对心脏衰老或修复过程中起作用的分子决定因素的理解仍然有限。在这里，我们将总结心脏衰老过程中发生的分子和生理变化，强调长链非编码RNA（lncRNA）作为心脏再生/修复中新的有价值靶点的潜在作用。
