Saderi Nadia, Escobar Carolina, Salgado-Delgado Roberto
Facultad de Ciencias, Universidad Autonoma de San Luis Potosi, San Luis de Potosi, Mexico.
Rev Neurol. 2013 Jul 16;57(2):71-8.
The incidence of obesity worldwide has become a serious, constantly growing public health issue that reaches alarming proportions in some countries. To date none of the strategies developed to combat obesity have proved to be decisive, and hence there is an urgent need to address the problem with new approaches. Today, studies in the field of chronobiology have shown that our physiology continually adapts itself to the cyclical changes in the environment, regard-less of whether they are daily or seasonal. This is possible thanks to the existence of a biological clock in our hypothalamus which regulates the expression and/or activity of enzymes and hormones involved in regulating our metabolism, as well as all the homeostatic functions. It has been observed that this clock can be upset as a result of today's modern lifestyle, which involves a drop in physical activity during the day and the abundant ingestion of food during the night, among other factors, which together promote metabolic syndrome and obesity. Hence, the aim of this review is to summarise the recent findings that show the effect that altering the circadian rhythms has on the metabolism and how this can play a part in the development of metabolic diseases.
全球肥胖症的发病率已成为一个严重且持续增长的公共卫生问题，在一些国家达到了惊人的比例。迄今为止，为对抗肥胖症所制定的策略均未被证明具有决定性作用，因此迫切需要用新方法来解决这一问题。如今，生物钟学领域的研究表明，我们的生理机能会不断地使自身适应环境的周期性变化，无论这些变化是每日的还是季节性的。这之所以成为可能，得益于我们下丘脑内存在的生物钟，它调节着参与调节新陈代谢以及所有体内平衡功能的酶和激素的表达及/或活性。据观察，由于当今的现代生活方式，生物钟可能会被打乱，这种生活方式包括白天身体活动减少以及夜间大量摄入食物等因素，这些因素共同促成了代谢综合征和肥胖症。因此，本综述的目的是总结近期的研究发现，这些发现表明改变昼夜节律对新陈代谢的影响以及这如何在代谢疾病的发展中发挥作用。
