Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Ataşehir, 34752 Istanbul, Turkey.
Acibadem Labmed Clinical Laboratories, Ataşehir, 34752 Istanbul, Turkey.
Int J Mol Sci. 2023 Mar 27;24(7):6275. doi: 10.3390/ijms24076275.
The concentration of biomolecules in living systems shows numerous systematic and random variations. Systematic variations can be classified based on the frequency of variations as ultradian (<24 h), circadian (approximately 24 h), and infradian (>24 h), which are partly predictable. Random biological variations are known as between-subject biological variations that are the variations among the set points of an analyte from different individuals and within-subject biological variation, which is the variation of the analyte around individuals' set points. The random biological variation cannot be predicted but can be estimated using appropriate measurement and statistical procedures. Physiological rhythms and random biological variation of the analytes could be considered the essential elements of predictive, preventive, and particularly personalized laboratory medicine. This systematic review aims to summarize research that have been done about the types of physiological rhythms, biological variations, and their effects on laboratory tests. We have searched the PubMed and Web of Science databases for biological variation and physiological rhythm articles in English without time restrictions with the terms "Biological variation, Within-subject biological variation, Between-subject biological variation, Physiological rhythms, Ultradian rhythms, Circadian rhythm, Infradian rhythms". It was concluded that, for effective management of predicting, preventing, and personalizing medicine, which is based on the safe and valid interpretation of patients' laboratory test results, both physiological rhythms and biological variation of the measurands should be considered simultaneously.
生物分子在生命系统中的浓度表现出许多系统和随机的变化。系统变化可以根据变化的频率进行分类，分为超日节律（<24 小时）、昼夜节律（约 24 小时）和超日节律（>24 小时），其中部分是可预测的。随机生物变化被称为个体间生物变化，即不同个体分析物设定点之间的变化，以及个体内生物变化，即分析物围绕个体设定点的变化。随机生物变化是不可预测的，但可以通过适当的测量和统计程序来估计。生理节律和分析物的随机生物变化可以被认为是预测性、预防性，特别是个体化实验室医学的基本要素。本系统评价旨在总结关于生理节律、生物变化及其对实验室检测影响的研究。我们在 PubMed 和 Web of Science 数据库中以英文搜索了没有时间限制的生物变化和生理节律文章，使用的术语是“Biological variation, Within-subject biological variation, Between-subject biological variation, Physiological rhythms, Ultradian rhythms, Circadian rhythm, Infradian rhythms”。结论是，为了有效管理基于患者实验室检测结果的安全有效解释的预测、预防和个体化医学，应同时考虑生理节律和测量值的生物变化。
